E-Dissertationen: Suche
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Pharmacometric approaches for linking pharmacokinetic and pharmacodynamic models of sunitinib and pazopanib with clinical outcome
(2019-07-22)
Aim of this thesis was to build a modeling framework for patients with metastatic renal cell carcinoma (mRCC) treated with two common first-line therapies, sunitinib and pazopanib. Therefore, as part of the European-wide ...
FR900359, an inhibitor of guanine nucleotide dissociation, effectively blunts signaling of GTPase-deficient Gq: mechanism of action and relevance for treating Gq-driven cancers
(2019-08-01)
Uveal melanoma (UM), the most common cancer of the adult eye, is known to have poor prognosis. Over 50% of patients are likely to develop metastasis. In more than 80% of the cases UM is driven by an activating mutation in ...
Impact of ERK signaling and its spatial regulation on cisplatin sensitivity in ovarian cancer cells
(2019-11-08)
The efficiency of the anticancer drug cisplatin in ovarian cancer is often limited by the development of cisplatin resistance. Cisplatin activates a plethora of DNA damage-related signaling pathways, which regulate the ...
Einfluss der tRNA Modifikation i6A37 auf die Translation in Säugern und deren Mitochondrien
(2019-10-17)
Modifizierte Basen in tRNA-Anticodonschleifen üben einen direkten Einfluss auf die Translationsmaschinerie aus. N6-Isopentenyladenosin (i6A) ist die älteste bekannte tRNA-Modifikation. Jedoch war ihre ......
Platelet-immune cell interactions in inflammation and cancer
(2019-09-10)
Platelets are well-known for their role in hemostasis and only more recently, they have also been acknowledged for their immune regulatory roles. Despite being small sized and anucleated, they can respond to inflammatory ...
Application of Sensitive API-Based Indicators and Numerical Simulation Tools to Advance Hot-Melt Extrusion Process Understanding
(2019-09-11)
This dissertation explored the use of active pharmaceutical ingredients (APIs) as indicator substances as well as numerical process simulation to enhance process understanding of hot-melt extrusion (HME) in the pharmaceutical ......
Mechanisms of epileptogenesis in animal models of developmental brain lesions
(2021-11-05)
Developmental brain lesions, including glioneuronal tumors (GNT) and malformations of cortical development (MCD), are among the most common causes for pharmaco-resistant epilepsy. Despite substantial differences, their ...
The role of the zinc finger transcription factor Gli3 in murine hindbrain development
(2019-07-15)
The zinc finger transcription factor GLI3 is a downstream component of the Sonic Hedgehog signaling pathway and functions mostly as a transcriptional repressor. GLI3 is required for the proper development of dorsal forebrain, ......
Der Zinkfinger-Transkriptionsfaktor GLI3 ist eine der nachgeschalteten Komponenten des Sonic Hedgehog Signalwegs, und fungiert hauptsächlich als transkriptioneller Repressor. GLI3 ist für die normale Entwicklung des dorsalen ......
Der Zinkfinger-Transkriptionsfaktor GLI3 ist eine der nachgeschalteten Komponenten des Sonic Hedgehog Signalwegs, und fungiert hauptsächlich als transkriptioneller Repressor. GLI3 ist für die normale Entwicklung des dorsalen ......
Characterization of VKORC1L1 with respect to VKORC1
(2019-07-10)
Vitamin K reduction is essential and catalyzed by two enzymes in vitro. Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) reduces vitamin K to sustain γ-carboxylation of vitamin K dependent (VKD) proteins. This ...
Investigation on the diversity and antimicrobial potential of marine predatory bacteria enabled elucidation of the thio-peptide kocurin and aminophenylpyrrole-derived alkaloids biosynthesis
(2019-07-17)
Bacteria are a remarkable source of bioactive compounds, of which many served as lead compounds for the development of medicinal drugs currently used for diverse applications in clinic. Despite the immense bacterial ...