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Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients
(2020-03-19)
The cancer therapy of older patients is challenging, being more complex than the therapy of younger patients. Older cancer patients show a higher toxicity risk during therapy and drug-related problems are common. In order ...
A humanized zebrafish screening platform to identify GPR17 inhibitors for the treatment of multiple sclerosis
(2020-02-19)
Multiple sclerosis (MS), a demyelinating disease of the central nervous system (CNS) with dev-astating symptoms, is characterized by the progressive destruction of myelin and myelinating oligodendrocytes (Ol). Currently, ...
Ryanodine Receptor 2 (RyR2) underlies maintenance and remodeling of dendritic spines
(2020-03-09)
The human brain comprises 1012 neurons that receive, integrate and transmit electrochemical signals. This complex network constantly re-adapts during an animal’s lifetime. All sensed experiences refine neurons via ...
Molecular pharmacological analysis of the human MrgD receptor: New insights into signaling
(2021-08-09)
Introduction: MrgD is a member of the MAS-related GPCRs family. It has been proposed to play roles in nociception and cardiovascular control. MrgD has been shown to couple to Gq, Gi, and Gs proteins. The ...
The enzyme HPGD is critical for regulatory T cell function in adipose tissue
(2020-02-06)
Regulatory T cells (Treg cells) are essential for maintaining immune homeostasis. However, how Treg cells exert their function in tissue specific environments is often unknown. We have found ......
Contributions towards a better understanding of millipede phylogenetics and sawfly genomics
(2021-03-11)
A loss of biodiversity on a scale and rate comparable to the great extinction events, as a result of anthropogenic activity, has been documented for plants, animals, and micro-organisms. In order to foster a sustainable ...
Mapping intra- and inter-annual dynamics in wetlands with multispectral, thermal and SAR time series
(2019-10-23)
Kartierung der intra- und interannuellen Dynamik von Feuchtgebieten mit multispektralen, thermischen und SAR-Zeitreihen
Die Analyse der aktuellen räumlichen Verbreitung und der zeitlichen Entwicklung ...
Die Analyse der aktuellen räumlichen Verbreitung und der zeitlichen Entwicklung ...
Die Aufklärung eines neuartigen Pentose-Stoffwechsels und die Möglichkeit einer Homosuccinat-Fermentation in Darmbakterien
(2022-08-26)
In der vorliegenden Arbeit wurde der Pentose-Metabolismus des bedeutsamen Darmbakteriums Prevotella copri (P. copri) untersucht, und es wurde analysiert, ob die Umsetzung einer Homosuccinat-Fermentation mit dem Darmbakterium ......
Synthesis and structure-activity relationships of CD39 and CD73 inhibitors
(2022-08-13)
Ecto-nucleoside triphosphate diphosphohydrolase-1 (NTPDase1 or CD39) is a member of the membrane-bound ecto-nucleotidase family, which catalyzes the extracellular hydrolysis of pro-inflammatory ATP and pro-thrombotic ADP ......