E-Dissertationen: Search
Now showing items 521-530 of 627
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Synthese, Testung und 3D-QSAR von ABCG2-Inhibitoren
(2021-08-09)
Die Behandlung von Krebserkrankungen baut im Allgemeinen auf verschiedenen Säulen auf, wobei die Chemotherapie eine der wichtigsten Therapiemethoden darstellt. Ein häufiges Versagen der Chemotherapie beruht auf der ......
Synthesis, Investigation and 3D-QSAR Analysis of ABCG2 Inhibitors
Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the ......
Synthesis, Investigation and 3D-QSAR Analysis of ABCG2 Inhibitors
Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the ......
Cisplatin resistance is associated with altered signalling in NSCLC cells
(2018-01-18)
The efficacy of cisplatin-based chemotherapy in cancer is limited by the occurrence of innate and acquired drug resistance. In order to better understand the mechanisms underlying acquired cisplatin resistance, the ...
Pharmacokinetic-pharmacodynamic modeling of antibacterial agents in tissues and body fluids
(2020-11-25)
The aim of this thesis was to assess the pharmacokinetic / pharmacodynamics (PK/PD) of anti-bacterial agents in tissues and body fluids through non-linear mixed effects (NLME) modeling.
In the first project, a ...
In the first project, a ...
Untersuchung der präferentiellen und alternativen Signalwegsaktivierung muskarinischer M2- und M4-Rezeptoren mithilfe von molekularen Testsonden
(2018-02-16)
Die muskarinischen Acetylcholinrezeptoren gehören zur Superfamilie der 7-Transmembranrezeptoren. Die in der vorliegenden Arbeit betrachteten M2- und M4-Rezeptoren weisen eine präferentielle Kopplung ...
Deciphering the role of the deubiquitinating enzyme Ataxin-3 in transcriptional regulation and the cellular response to stress
(2018-12-19)
Ataxin-3 (ATXN3), the disease-causing protein for Machado Joseph Disease (MJD) is functionally involved in the protein quality control and transcriptional regulation of various genes. Recent data suggest that either ...
Scalable Algorithms for Parallel Tree-based Adaptive Mesh Refinement with General Element Types
(2018-12-12)
In this thesis, we develop, discuss and implement algorithms for scalable parallel tree-based adaptive mesh refinement (AMR) using space-filling curves (SFCs). We create an AMR software that works independently of the used ...
Vom Schuss zur Spur: Molekulargenetische Analysen von Rückschleuderspuren nach Schüssen auf biologische Ziele
(2018-11-16)
Pro Jahr werden in Deutschland mehrere Tausend Straftaten mit Schusswaffengebrauch registriert. Die Aufklärung des meist komplexen Szenarios durch eine objektive und allumfassende Rekonstruktion des entsprechenden Tathergangs ...
The role of soluble guanylate cyclase in metabolism
(2018-10-31)
Obesity is a worldwide health problem characterized by a chronic positive energy balance. The excess energy is stored primarily as lipids (TGs) in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) utilizes ...
Biophysical studies of EGFR conformation and interaction
(2019-03-26)
Epidermal growth factor receptor (EGFR) plays such a crucial role in cell signaling that its activity is intricately regulated. According to the prevailing activation model, EGF binding to EGFR initiates a series of ......