E-Dissertationen: Search
Now showing items 541-550 of 627
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...
Sphärische Lyophilisate zur pulmonalen Proteinapplikation
(2019-07-12)
Die pharmazeutische Sprüht-Gefrier-Trocknung (Spray-Freeze-Drying) umfasst ein heterogenes Feld von Technologien mit primären Anwendungen in den Bereichen Löslichkeitsverbesserung, pulmonale und nadelfreie intra-dermale ...
Development and Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Population Model for Elderly Individuals
(2019-07-04)
Clinical drug development is traditionally focused on young and middle-aged adults. The elderly are often underrepresented in clinical trials, even though persons aged 65 years and older receive the majority of drug ...
Knowledge Management approaches to model pathophysiological mechanisms and discover drug targets in Multiple Sclerosis
(2019-04-30)
Multiple Sclerosis (MS) is one of the most prevalent neurodegenerative diseases for which a cure is not yet available. MS is a complex disease for numerous reasons; its etiology is unknown, the diagnosis is not exclusive, ...
Analyzing feedbacks in a forest soil-vegetation-atmosphere system
(2019-05-03)
In this study, the soil-vegetation-atmosphere system of a 38 ha forested headwater catchment in the Eifel region (western Germany) was analyzed with the aim to improve the understanding of the impacts of climate forcings ......
In dieser Arbeit wurden verschiedene Rückkopplungen im Boden-Pflanze-Atmosphärensystem eines 38 ha großen bewaldeten Einzugsgebietes in der Eifel (Westdeutschland) analysiert. Ziel war, das Verständnis der Auswirkungen von ......
In dieser Arbeit wurden verschiedene Rückkopplungen im Boden-Pflanze-Atmosphärensystem eines 38 ha großen bewaldeten Einzugsgebietes in der Eifel (Westdeutschland) analysiert. Ziel war, das Verständnis der Auswirkungen von ......
Analysis of Multitarget Activities and Assay Interference Characteristics of Pharmaceutically Relevant Compounds
(2019-05-29)
The availability of large amounts of data in public repositories provide a useful source of knowledge in the field of drug discovery. Given the increasing sizes of compound databases and volumes of activity data, computational ...
On some Geometric Search Problems: Algorithms, Complexity, Computability
(2020-11-25)
This thesis considers four search problems which are related to or emerge from a geometric context. Each search problem is examined in a separate chapter; these four chapters are framed by an introduction and a conclusion ...
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)
Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
The Impact of CD44 and Osteopontin on Hematopoiesis
(2021-10-25)
Hematopoiesis is the process, which enables the replenishment of blood cellular components in mammals throughout their lifespan. Hematopoietic stem cells (HSC), which reside within the bone marrow (BM), are the primary ...
Electrostatic anchoring of SNAP25 to the plasma membrane
(2021-07-21)
Neurotransmission is based on incredibly rapid membrane trafficking cycles, mediating the release of neurotransmitters. The fusion machinery of the well-studied SNARE protein complex ensures the speed and precision of ...