E-Dissertationen: Suche
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Electronic Structure Studies of Iron-Sulfur Clusters: from Model Compounds to the Active Site of Nitrogenase
(2022-08-23)
Iron-sulfur (FeS) clusters are omnipresent in nature, where they are involved in a variety of tasks, such as electron transfer, DNA repair, Fe storage, and substrate activation. The enzyme nitrogenase contains one of the ...
Sesquiterpenanalytik in Weinbeeren und Weinen mittels GC×GC–TOF–MS
(2022-08-05)
Sesquiterpene sind chemische Verbindungen, die aus drei Isopren-Einheiten bestehen und zur größten und strukturell vielfältigsten Klasse von Naturstoffen, den Terpenen, zählen.
In Weinbeeren (Vitis vinifera L.) ......
Analysis of sesquiterpenes in grapes and wines using GC×GC–TOF–MS
Sesquiterpenes are chemical compounds consisting of three isoprene units and belong to the largest and most structurally diverse ......
In Weinbeeren (Vitis vinifera L.) ......
Analysis of sesquiterpenes in grapes and wines using GC×GC–TOF–MS
Sesquiterpenes are chemical compounds consisting of three isoprene units and belong to the largest and most structurally diverse ......
Elucidating Intricate Solvation Phenomena via In Silico Experiments: The OH Radical in Aqueous Environments and Keratin in Ionic Liquids
(2022-10-18)
In this thesis, complicated solvation phenomena that are impossible to observe via laboratory experiments are comprehensively investigated by molecular dynamics (MD) simulations. The OH radical effectively cleanses the ......
Ligandenfeldanalyse im Rahmen des Angular Overlap Model an einer Reihe von Samarium(III)-oxoverbindungen mit ergänzenden Betrachtungen zu Europium(III)-oxoverbindungen
(2022-10-17)
Diese Arbeit stellt die Ligandenfeldanalyse von Samarium(III)- und Europium(III)-oxoverbindungen, sowie von Samarium(III)- und Europium(III)-fluorid vor. Die Ligandenfeldanalysen wurden im Rahmen des Angular Overlap Model ...
Modulation der Gαi1/s-Proteinaktivität durch lineare und makrozyklische Peptide
(2021-07-08)
Die vorliegende Dissertation beschäftigt sich mit der Identifizierung und Charakterisierung von peptidischen Modulatoren für die Gαi/s-Proteinaktivität. Die Ga-Untereinheit heterotrimerer G-Proteine ist eine bedeutende ...
OptoRiboGenetics: Post-transcriptional control of gene expression by light
(2021-08-26)
Gene expression is tightly regulated in mammalian cells at the post transcriptional level and its precise manipulation has proven to be valuable for protein overexpression and gene therapy. Implementation of light-responsive ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
Investigation of Quinazoline Derivatives as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)
(2018-03-12)
The treatment of cancer with chemotherapeutic drugs is strongly limited by intrinsic or aquired resistance of the cancer cells. This is the main reason of a failure of the therapy. The cellular resistance mostly originates ...
Development and Application of Efficient Methods for the Computation of Electronic Spectra of Large Systems
(2018-04-13)
In this thesis, an efficient procedure to compute electronic excitation spectra of molecular systems is presented, focusing particularly on the computation of electronic circular dichroism (ECD) spectra. ECD spectroscopy ...
Mechanistic Investigation of a HAuCl4 catalyzed oxidative C-C coupling reaction and Synthesis of new supramolecular Silver(I) and Gold(I) NHC compounds: or handling of a Mass Spectrometric Challenge and catching Counterions on Supramolecular Playgrounds
(2021-04-22)
Reaction monitoring by electrospray (ESI) mass spectrometry is a valuable technique to investigate reaction mechanisms. It allows a glimpse into the reacting solution and the characterization of transient intermediates ......
EPR distance measurements using triaryl methyl radicals and EPR investigation of electron transfer processes in organic radicals
(2018-04-17)
EPR is a valuable tool for the investigation of biological structures. Most EPR-based distance measurements rely on the site directed spin labeling of the investigated biomolecule, since most biomolecular structures do not ...