E-Dissertationen: Suche
Anzeige der Dokumente 71-80 von 255
Mechanisms of T cell mediated kidney disease
(2010-01-06)
Immune mediated glomerulonephritis (GN) is a major cause renal inflammation leading to terminal kidney failure. B cells and autoantibodies are well known to contribute to the progression of glomerular disease. The role of ...
Lysine-specific histone demethylase 1 (LSD1): A novel molecular target for tumor therapy
(2010-01-27)
Aberrant epigenetic changes in DNA methylation and histone acetylation are hallmarks of most cancers, while histone methylation had been considered to be irreversible and less versatile. Recently, several histone demethylases ...
Identifying Genetic Basis and Molecular Mechanisms in Different Types of von Willebrand Disease (VWD)
(2013-08-22)
Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It is caused by quantitative or qualitative defects of the von Willebrand factor (VWF) which has crucial roles in hemostasis. VWD is classified ...
Analytik und Eignung von Biomarkern zur Vorhersage der Wirksamkeit von Sunitinib mit Hilfe von pharmakokinetischen/pharmakodynamischen Modellen
(2013-05-07)
Im Rahmen der Dissertation sind die Analytik und die Eignung von Biomarkern (sVEGFR 2 und -3) zur Vorhersage der Wirksamkeit von Sunitinib mit Hilfe der PK/PD-Modellierung in einer multizentrischen Studie bei Patienten mit ...
Development of New Breast Cancer Resistance Protein Inhibitors
(2013-07-09)
Chemotherapy is a major form of treatment for cancers. Unfortunately, the majority of cancers are either resistant to chemotherapy or acquire resistance (MDR) during treatment. The most common mechanism by which human ...
Die Biosynthese und der Transport von N-Acetylaspartylglutamat und N-Acetylaspartylglutamylglutamat
(2013-07-10)
N-Acetylaspartylglutamat (NAAG) ist eines der höchst konzentrierten Neuropeptide im Nervensystem von Säugetieren. Neben der postulierten Rolle als Agonist für den Typ II metabotropen Glutamatrezeptor 3. Zusätzlich dient ...
Investigations into interferon response of novel bat cell cultures upon alphavirus infection
(2013-06-13)
Bats have been identified as reservoir for human pathogenic zoonotic viruses like Rabies, Marburg or Henipaviruses. The fact that bats carry viruses without showing clinical symptoms, raised the question if these flying ...
Multi-scale targeting of land degradation in northern Uzbekistan using satellite remote sensing
(2013-11-13)
Advancing land degradation (LD) in the irrigated agro-ecosystems of Uzbekistan hinders sustainable development of this predominantly agricultural country. Until now, only sparse and out-of-date information on current land ...
eCTD - Neue Wege der elektronischen Einreichung: Vernetzung elektronischer regulatorischer Prozesse
(2013-12-13)
Die Arzneimittelzulassung ist mit der Einführung des eCTD – Standards dem erklärten Ziel der papierlosen Einreichung einen großen Schritt näher gekommen. Seit nun mehr als 20 Jahren arbeiten Behörden und Antragssteller ...
Phytochemical and analytical studies of feed and medicinal plants in relation to the presence of toxic pyrrolizidine alkaloids
(2013-10-28)
Pyrrolizidine alkaloids (PAs) are wide-spread in the plant kingdom; they are present in approximately 3 % of all flowering plants. Unsaturated PAs possess hepatotoxic, carcinogenic, genotoxic, teratogenic properties.