E-Dissertationen: Browsing E-Dissertationen by Classification (DDC) "ddc:500"
Now showing items 1-20 of 42
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Blutungsbedingte Nebenwirkungen der Therapie des Blepharospasmus und Hemispasmus facialis mit Botulinumneurotoxin unter antithrombotischer Medikation
(2024-03-04)Ziel der Studie war es die Häufigkeit und Tragweite blutungsbedingter Nebenwirkungen der Behandlung des benignen essentiellen Blepharospasmus (BEB) und Hemispasmus facilais (HFS) mit Botulinumneurotoxin A (BoNT/A) unter ... -
Control of pulmonary immunity by physical exercise
(2024-03-06)Sedentary lifestyles combined with high caloric nutrition are widely known to severely contribute to the rise of metabolic diseases like diabetes, atherosclerosis, or obesity in recent years. While endurance training has ... -
Die Rolle des C-Typ-Lektin-Rezeptors 4e in der Atherogenese
(2023-06-22)CVD und deren Hauptursache Atherosklerose stellen auch heute noch die weltweit häufigste Todesursache dar. Deren Entstehung ist ein intensiv erforschter Prozess und im Laufe der Zeit konnten zahlreiche Risikofaktoren der ... -
The Effects of Orciprenaline on the Contractility of Isolated Cardiomyocytes under Septic Conditions Mediated by Lipopolysaccharide
(2018-07-06)The septic cardiomyopathy is associated with a high morbidity and mortality. In a sepsis, the contractility of a cardiomyocyte is reduced significantly. Consecutively, the cardiac output of the heart is compromised. This ... -
Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
(2023-03-23)<strong>Einleitung:</strong> Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ... -
Endocannabinoid system and the aging locus coeruleus
(2022-11-28)The locus coeruleus (LC) is a small nucleus located in the pons of the brainstem, representing the major source of noradrenaline (NE) in the central nervous system. Although the LC consists of a relatively low number of ... -
Entwicklung und Evaluation einer quantitativen „one-step“ RT-PCR zur Bestimmung von CD103 im Urin
(2008)<p>Bei unklarer Genese einer Funktionseinschränkung von Nierentransplantaten wird meist eine Biopsie durchgeführt, die bis heute als diagnostischer Goldstandard gilt. Um die mit einer Biopsie verbundenen Risiken zu vermeiden, ... -
Functional and cellular heterogeneity of the myeloid cell system
(2020-11-09)Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ... -
Immune defense mechanisms against Legionella longbeachae
(2020-01-30)The pulmonary epithelial barrier is the first line of defense against pathogens invading the lungs. If those are able to overcome this first barrier, myeloid cells of the innate immune system are instrumental for the ... -
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
(2021-10-26)Die Alzheimer-Krankheit stellt die weltweit häufigste Form der Demenz dar. Die genauen Mechanismen, welche zu ihrer Entstehung führen, sind bis heute nicht vollständig verstanden. Eine wichtige Rolle spielt die Aktivierung ... -
Impact of chronic liver inflammation on adaptive immune responses to viral infection
(2020-03-11)A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ... -
Inducing immunity to liver stage malaria through endogenous tissue resident memory cells
(2020-12-16)Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ... -
Influence of antiviral RNA binding effector proteins on innate immune responses
(2024-08-06)The efficient elimination of viruses is initiated by the recognition of the viral nucleic acid genome or replication intermediates through innate immune receptors. Several different receptors specifically detect double ... -
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ... -
Investigating the Role of Nucleic Acid Sensing in the Pathogenesis of Chronic Viral Infection-Induced Chronic Kidney Disease and Autoimmunity
(2025-02-25)Patients with chronic HIV infections, are at increased risk of developing comorbidities, with chronic kidney disease (CKD) such as immune complex glomerulonephritis (ICGN) being particularly common. Diagnosis of ICGN ... -
Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)The 21<sup>st</sup> amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ... -
Local synthesis of steroid hormones in human hair roots
(2025-02-17)Hair loss displays a common symptom with a multitude of different origins that complexes diagnostics and therapy. <br /> The basis of the current project was the hypothesis, that hair loss may be correlated or even ... -
Mechanisms underlying the effects of context on food decisions in humans
(2023-05-25)Food decisions are inevitable, frequent, and complex decisions with a high impact on our health. Understanding the mechanisms that underly food decisions has become a multidisciplinary endeavor over the last decades, ... -
Modulation der antibakteriellen Immunantwort in Blut und Aszites durch von Immunzellen produzierten Katecholamine bei Patienten mit Leberzirrhose
(2024-01-05)<strong>Hintergrund und Ziele:</strong> Der Verlauf einer Leberzirrhose mit Aszites kann durch verschiedenste Parameter beeinflusst werden. Im Rahmen der vorliegenden Arbeit wurde untersucht, ob Immunzellen im Blut und / ... -
Participation of Ste20-like kinase-deficient neurons in the abnormal circuitry of focal epileptogenic lesions
(2022-01-03)Focal epileptogenic lesions displaying morphologically altered neurons are frequently associated with devastating and therapy-refractory epilepsies. However, it is still unsolved how dysplastic neurons contribute to the ...
