E-Dissertationen: Search
Now showing items 61-70 of 85
RIM4 deficiency leads to reduced somato-dendritic excitability of cerebellar Purkinje cells
(2023-12-14)
Synaptic function is determined by the release machinery at the active zone which is composed of a large number of synaptic proteins including RIMs. The large RIMs are key components of the presynaptic active zone that ...
Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration
(2023-02-14)
Brain aging is a multifactorial process including accumulation of aged lipids and proteins,
neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling ...
The interplay of fatty acid synthesis, metabolism, and immune function during Flavivirus infection
(2023-10-04)
Macrophage activation and Flavivirus infection can both fundamentally alter cellular metabolism and change the lipid landscape of cells. Flaviviruses upregulate fatty acid synthesis to build membranous replication complexes, ...
From pattern recognition to pro-inflammatory cell death - Functional characterization of the proteins NLRP7 and GSDMD
(2023-12-07)
Inflammasomes are cytosolic multi-protein complexes that form in response to infection or other harmful stimuli to induce innate immune responses. The core components of inflammasomes are pattern recognition ...
Deciphering the role of human-specific genes in the development of the human neocortex
(2024-01-04)
The human brain is remarkably complex and has been subject to noteworthy changes throughout evolution. An expansion of progenitor cells is thought to contribute to the complexity and increase in cortical size that is ......
Characterisation of Inflammasome-Induced Extracellular Vesicles, Their Uptake by and Effect on Bystander Cells
(2023-12-22)
Inflammasomes are multimeric complexes whose activation triggers caspase 1 cleavage resulting in processing of the cytokines interleukin (IL) 1β and IL-18, and the pore-forming protein gasdermin D. This, in turn, initiates ...
Platelets shape the immune response of primary human monocytes
(2023-01-13)
Monocytes are circulating immune cells essential to host defense, orchestrating immune responses through the secretion of immunomodulatory mediators. While exuberant monocyte-driven immune responses have life-threatening ...
Programmed cell death regulation during Salmonella Typhimurium infections
(2024-01-18)
Programmed cell death (PCD) is a highly regulated process that is vital for the development and homeostasis of multicellular organisms. It functions as an essential mechanism to remove dispensable or unfavourable cells in ......
Cellular and molecular defence mechanisms against Legionella infection
(2024-01-26)
The two most prevalent causes of Legionnaires’ disease are L. pneumophila and L. longbeachae. The rising incidence of the Legionnaires’ disease over the past two decades together with the increasing prevalence of L. ......
Return of the first inflammasome: Elucidation of NLRP1 inflammasome activation by p38-mediated phosphorylation and ubiquitination
(2024-01-30)
The assembly of inflammasomes is linked to the detection of pathogens and other danger signals by intracellular pattern-recognition receptors of the mammalian innate immune system. The human inflammasome sensor NLRP1 is ...