Medizinische Fakultät: Medizinische Fakultät: Neuzugänge
Anzeige der Dokumente 301-320 von 2398
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G-quadruplex stabilization potentiates anti-tumor immune responses and sensitizes cold tumors for checkpoint therapy
(2025-08-20)Checkpoint inhibitors have revolutionized cancer therapy and improved patient survival in many cancers. However, even in well-responding entities such as melanoma, about 50% of patients are primarily resistant or develop ... -
Einfluss der Wachstumsmatrix auf die Differenzierung von Mausmakrophagen zu Osteoklasten-ähnlichen Zellen
(2025-08-19)Externe apikale Wurzelresorptionen (EAWR) stellen eine schwerwiegende Nebenwirkung der kieferorthopädischen Zahnbewegung dar, die mit einem irreversiblen Verlust radikulärer Hartgewebe einhergeht. Verantwortlich hierfür ... -
Der Zebrafisch als Modellorganismus kongenitaler Muskeldystrophien am Beispiel der Protein-O-Mannosyltransferase 1-Defizienz
(2025-08-19)Der Zebrafisch eignet sich aufgrund der evolutionären Konservierung der Skelettmuskulatur als potenter Modellorganismus kongenitaler Muskelerkrankungen. In dieser Arbeit soll anhand des Beispiels der Protein-O-Mannosyltr ... -
PBRM1 loss in clear cell renal cell carcinoma leads to a proangiogenic phenotype via the CXCL5/CXCR2 axis that can be targeted by CXCR2 inhibition
(2025-08-18)Immune checkpoint blockade (ICB) and anti-angiogenic tyrosine kinase inhibitors (TKI) have substantially improved the outcomes of metastatic clear cell renal cell carcinoma (ccRCC). Nevertheless, the anti-angiogenic TKIs ... -
Postoperative Nervus femoralis Läsionen in der gynäkologischen Onkologie
(2025-08-18)Die meisten Verletzungen des Nervus femoralis sind iatrogen bedingt und treten nach chirurgischen Eingriffen auf. Auch wenn sie meist eine gute Prognose haben, kann eine spontane Heilung Monate andauern und somit den ... -
Einfluss von hypoxisch-ischämischem Hirnschaden auf die Neurogenese und das strukturelle sowie funktionelle Outcome im Rattenmodell
(2025-08-15)<strong>Hintergrund und Zielsetzung:</strong><br/> Die hypoxisch-ischämische Enzephalopathie (HIE) bei Neugeborenen entsteht durch eine mangelhafte Versorgung des Gehirns mit Sauerstoff und Nährstoffen rund um die Geburt. ... -
Ärztliches Verordnungsverhalten von Laboranalysen am Beispiel des Serummagnesiums: Eine Vorher-/Nachher-Studie mit unterbrochenen Zeitreihen
(2025-08-13)Die strukturellen Einflüsse auf die Entscheidungsfindung in der medizinischen Versorgung wurden bislang nur unzureichend untersucht. <br/> Die durchgeführte Studie widmet sich einem Teilaspekt dieser Problemstellung, indem ... -
33/m: Komplettierung des Impfstatus vor Praktikum in Kindertagesstätte: Vorbereitung auf die Facharztprüfung: Fall 52
(2024-07-11)<strong>Prüfungssimulation</strong><br /> <strong><em>Fallschilderung</strong></em><br /> Ein 33-jähriger Student des Fachs Kindheitspädagogik möchte in 6 Wochen sein erstes Praktikum in einer Kindertagesstätte ... -
Mouse models of type I interferonopathies
(2024-12-16)Type I interferonopathies are severe monogenic diseases caused by mutations that result in chronically upregulated production of type I interferon. They present with a broad variety of symptoms, the mechanisms of which are ... -
IDEAL–compliant implementation of the Dexter® surgical robot in cholecystectomy: A comprehensive framework and clinical outcomes
(2024-12-30)<strong>Objectives:</strong> The integration of advanced technologies is transforming surgical practice, particularly through robotic systems. This study presents the early clinical implementation of the Dexter<sup>®</sup> ... -
Longitudinal Study of SARS-CoV-2 Vaccinations and Infections in Patients with Gastrointestinal Cancer: Stabilizing Immune Responses and Neutralizing Emerging Variants with Variant-Adapted Antigen Exposures
(2024-12-19)This longitudinal study examined how active gastrointestinal (GI) cancer types affect immune responses to SARS-CoV-2, focusing on the ability to neutralize the Omicron variants. Patients with GI cancer (<em>n</em> = 168) ... -
Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma
(2023-10-17)<strong>Background & Aims:</strong> Vaccination with tumor-associated antigen-pulsed dendritic cells leads to specific T-cell response against hepato-cellular carcinoma. However, clinical response has been shown to be ... -
Epidemiology and outcomes of vancomycin-resistant enterococcus infections: A systematic review and meta-analysis
(2023-09-19)Vancomycin-resistant enterococci (VRE) cause many infections in the healthcare context. Knowledge regarding the epidemiology and burden of VRE infections, however, remains fragmented. We aimed to summarize recent studies ... -
Evaluating AI Courses: A Valid and Reliable Instrument for Assessing Artificial-Intelligence Learning through Comparative Self-Assessment
(2023-09-26)A growing number of courses seek to increase the basic artificial-intelligence skills ("AI literacy") of their participants. At this time, there is no valid and reliable measurement tool that can be used to assess AI-learning ... -
Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years
(2024-04-30)<strong>PURPOSE.</strong> To longitudinally assess the impact of high-risk structural biomarkers for natural disease progression in non-exudative age-related macular degeneration (AMD) on spatially resolved mesopic and ... -
Key factors for sustainable working conditions in emergency departments: An EUSEM-initiated, Europe-wide consensus survey
(2025-02)<em>Background and importance</em> Modern emergency medicine (EM) is a complex, demanding, and occasionally stressful field of work. Working conditions, provider well-being, and associated health and performance outcomes ... -
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function
(2024-04-29)Promoting brown adipose tissue (BAT) activity innovatively targetsobesity and metabolic disease. While thermogenic activation of BAT is wellunderstood, the rheostatic regulation of BAT to avoid excessive energy dissipation ... -
The Spectrum of Functional, Structural and Patient-Reported Outcomes in Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report
(2025-02-03)<em><strong>Introduction:</strong></em> There is an unmet medical need for therapies in intermediate age-related macular degeneration (iAMD). The prospective European multi-center cohort study MACUSTAR validates structural, ... -
TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies
(2024-12-23)<strong>Background</strong> Previous studies in mouse, <em>Xenopus</em> and zebrafish embryos show strong <em>tfap2e</em> expression in progenitor cells of neuronal and neural crest tissues suggesting its involvement in ... -
Ergebnisse von abdomino-thorakalen Eingriffen am Lymphgefäßsystem zur Behandlung traumatischer und nicht-traumatischer Lymphleckagen
(2025-08-11)<strong>Hintergrund:</strong><br /> Chylöse Ergüsse wie Chylothorax oder Chylaszites stellen seltene, aber schwerwiegende Krankheitsbilder dar, die häufig mit hoher Morbidität und Mortalität einhergehen. Ziel dieser Studie ...
