Institute: Browsing Institute by Title

Now showing items 1-20 of 68

    • 33/m: Komplettierung des Impfstatus vor Praktikum in Kindertagesstätte: Vorbereitung auf die Facharztprüfung: Fall 52 

      Dehnen, Dorothea; Reinsdorff, Melanie; Weltermann, Birgitta (2024-07-11)
      <strong>Prüfungssimulation</strong><br /> <strong><em>Fallschilderung</strong></em><br /> Ein 33-jähriger Student des Fachs Kindheitspädagogik möchte in 6 Wochen sein erstes Praktikum in einer Kindertagesstätte ...

    • Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators 

      Masala, Nicola; Mittag, Manuel; Ambrad Giovannetti, Eleonora; O'Neil, Darik A.; Distler, Fabian J.; Rupprecht, Peter; Helmchen, Fritjof; Yuste, Rafael; Fuhrmann, Martin; Beck, Heinz; Wenzel, Michael; Kelly, Tony (2024-07-23)
      Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using optical imaging. The viral transduction of GECIs is commonly used to target expression ...

    • Acceptability of surgical care in Uganda: a qualitative study on users and providers 

      Rauschendorf, Paula; Nume, Rosette; Bruchhausen, Walter (2023-07-31)
      <strong>Objectives</strong> This study was conducted to assess acceptability of surgical care in Eastern Uganda and enable better allocation of resources, and to guide health policy towards increased surgical care seeking.<br ...

    • Alterations in dopaminergic innervation and receptors in focal cortical dysplasia 

      Meli, Norisa; Sheran, Katherine; Pitsch, Julika; Krabbe, Sabine; Borger, Valeri; Baumgartner, Tobias; Becker, Albert; Blaess, Sandra (2025-04-16)
      Focal cortical dysplasia (FCD) type 2 is the most common malformation of cortical development associated with pharmaco-resistant focal epilepsy and frequently located in the frontal cortex. Neuropathological hallmarks ...

    • Arterial Blood Supply of the Stifle Joint in Horses 

      Schöpper, Hanna; Egerbacher, Monika (2024-04-24)
      The vascularization pattern of the equine stifle joint is insufficiently described in the literature, even though there is a growing need for knowledge of the exact blood supply, as (i) arthroscopy and endoscopic surgery ...

    • Assessing Electronic Health Literacy in Individuals With the Post–COVID-19 Condition Using the German Revised eHealth Literacy Scale: Validation Study 

      Marsall, Matthias; Dinse, Hannah; Schröder, Julia; Skoda, Eva-Maria; Teufel, Martin; Bäuerle, Alexander (2024-04-25)
      <strong>Background:</strong> The eHealth Literacy Scale (eHEALS) is a widely used instrument for measuring eHealth literacy (eHL). However, little is known so far about whether the instrument is valid for the assessment ...

    • Associations between COVID-19 Pandemic-Related Overtime, Perceived Chronic Stress and Burnout Symptoms in German General Practitioners and Practice Personnel: A Prospective Study 

      Küppers, Lucas; Göbel, Julian; Aretz, Benjamin; Rieger, Monika A.; Weltermann, Birgitta (2024-02-16)
      Background: The mental burdens of general practitioners (GPs) and practice assistants (PrAs) during the COVID-19 pandemic are well investigated. Work-related conditions like overtime are known to contribute to perceived ...

    • Barriers and Facilitators of Patient Engagement Activities to Improve Patient Safety in Healthcare Organizations: A Delphi-Based Expert Survey 

      Koch, Amelie; Brust, Larissa; Weigl, Matthias (2024-12-19)
      <strong>Purpose:</strong> In order to obtain sustainable healthcare, engagement of patients in patient safety improvement is vital. Drawing upon a multi-perspective approach, this study aimed to investigate perspectives ...

    • Bidirectional Effect of Long-Term Δ9‑Tetrahydrocannabinol Treatment on mTOR Activity and Metabolome 

      Bilkei-Gorzo, Andras; Schurmann, Britta; Schneider, Marion; Kraemer, Michael; Nidadavolu, Prakash; Beins, Eva C.; Müller, Christa E.; Dvir-Ginzberg, Mona; Zimmer, Andreas (2024-08-14)
      Brain aging is associated with cognitive decline, reduced synaptic plasticity, and altered metabolism. The activity of mechanistic target of rapamycin (mTOR) has a major impact on aging by regulating cellular metabolism. ...

    • Case Report: Practical approach to unmask unspecific adverse effects under lipid-lowering medication 

      Büttner, Thomas; Hartmann, Gunther; Coenen, Martin (2025-05-27)
      The nocebo effect, driven by negative expectations rather than pharmacological mechanisms, contributes significantly to medication non-adherence, particularly in lipid-lowering therapy. Up to 50% of reported statin-related ...

    • Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function 

      Khani, Sajjad; Topel, Hande; Kardinal, Ronja; Tavanez, Ana Rita; Josephrajan, Ajeetha; Larsen, Bjørk Ditlev Marcher; Gaudry, Michael James; Leyendecker, Philipp; Meincke Egedal, Nadia; Güller, Aylin Seren; Stanic, Natasa; Ruppert, Phillip M. M.; Gaziano, Isabella; Hansmeier, Nils Rouven; Schmidt, Elena; Klemm, Paul; Vagliano, Lara-Marie; Stahl, Rainer; Duthie, Fraser; Krause, Jens-Henning; Bici, Ana; Engelhard, Christoph Andreas; Gohlke, Sabrina; Frommolt, Peter; Gnad, Thorsten; Rada-Iglesias, Alvaro; Pradas-Juni, Marta; Schulz, Tim Julius; Wunderlich, Frank Thomas; Pfeifer, Alexander; Bartelt, Alexander; Jastroch, Martin; Wachten, Dagmar; Kornfeld, Jan-Wilhelm (2024-04-29)
      Promoting brown adipose tissue (BAT) activity innovatively targetsobesity and metabolic disease. While thermogenic activation of BAT is wellunderstood, the rheostatic regulation of BAT to avoid excessive energy dissipation ...

    • Comorbidity profiles among sputum-positive tuberculosis patients in Cameroon 

      Magha, Chefor; Nchang, Lucy Cho; Weldeslassie, Michael; Nkimbeng, Desmond Akumtoh; Tchatat, Nancielle Mbiatong; Meriki, Henry Dilonga; Deribe, Kebede; Nietcho, Frank Noel; Foyet, Juluis Visnel; Fombad, Fanny Fri; Katcho, Tatiana Djikeussi; Fru Cho, Jerome; Gebremeskel, Eyoab Iyasu; Waddell, Simon J.; Bobosha, Kidist; Newport, Melanie J.; Hoerauf, Achim; Ritter, Manuel; Wanji, Samuel (2024-10-02)
      <strong>Introduction:</strong> Comorbid non-communicable diseases (NCDs) like diabetes, cardiovascular diseases (CVD), kidney diseases, and hypertension, could have implications for tuberculosis (TB) treatment management ...

    • Comparative development of human filariae Loa loa, Onchocerca volvulus and Mansonella perstans in immunocompromised mouse strains 

      Chunda, Valerine C.; Fombad, Fanny Fri; Kien, Chi Anizette; Ebai, Rene; Esofi, Frederick; Ntuh, Anna Ning; Ouam, Emmanuel; Gandjui, Narcisse Victor Tchamatchoua; Ekanya, Relindis; Nietcho, Franck; Nchang, Lucy Cho; Magha, Chefor; Njouendou, Abdel Jelil; Enyong, Peter; Hoerauf, Achim; Wanji, Samuel; Ritter, Manuel (2024-04-15)
      <strong>Introduction:</strong> Mouse models of human filarial infections are not only urgently needed to investigate the biology of the nematodes and their modulation of the host's immunity, but will also provide a platform ...

    • Development of the "Scale for the assessment of non-experts' AI literacy": an exploratory factor analysis 

      Laupichler, Matthias Carl; Aster, Alexandra; Haverkamp, Nicolas; Raupach, Tobias (2023-09-27)
      Artificial Intelligence competencies will become increasingly important in the near future. Therefore, it is essential that the AI literacy of individuals can be assessed in a valid and reliable way. This study presents ...

    • Drinking Water and Sanitation Safety Planning for Medical Facilities: An Innovative PoU Approach for a Water System Description Using Ecomaps 

      Kamm, Lara; Hagen, Ralf M.; Mutters, Nico T.; Schmithausen, Ricarda M.; Weppler, Ruth; Döhla, Manuel (2025-06-26)
      Drinking Water Safety Plans (DWSP) in buildings serve to identify health hazards associated with the drinking water system. Sanitation Safety Plans (SSP) fulfill the same purpose for the sewage system. Water Safety Plans ...

    • Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors 

      Klausen, Christina; Kaiser, Fabian; Stüven, Birthe; Hansen, Jan N.; Wachten, Dagmar (2019-11-14)
      The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ...

    • In vitro extracellular replication of Wolbachia endobacteria 

      Behrmann, Lara Vanessa; Meier, Kirstin; Vollmer, Jennifer; Chiedu, Chukwuebuka Chibuzo; Schiefer, Andrea; Hoerauf, Achim; Pfarr, Kenneth (2024-07-18)
      Obligate intracellular endobacteria of the genus <em>Wolbachia</em> are widespread in arthropods and several filarial nematodes. Control programs for vector-borne diseases (dengue, Zika, malaria) and anti-filarial therapy ...

    • NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer 

      Klümper, Niklas; Tran, Ngoc Khanh; Zschäbitz, Stefanie; Hahn, Oliver; Büttner, Thomas; Roghmann, Florian; Bolenz, Christian; Zengerling, Friedemann; Schwab, Constantin; Nagy, Dora; Toma, Marieta; Kristiansen, Glen; Heers, Hendrik; Ivanyi, Philipp; Niegisch, Günter; Grunewald, Camilla Marisa; Darr, Christopher; Farid, Arian; Schlack, Katrin; Abbas, Mahmoud; Aydogdu, Can; Casuscelli, Jozefina; Mokry, Theresa; Mayr, Michael; Niedersüß-Beke, Dora; Rausch, Steffen; Dietrich, Dimo; Saal, Jonas; Ellinger, Jörg; Ritter, Manuel; Alajati, Abdullah; Kuppe, Christoph; Meeks, Joshua; Vera Badillo, Francisco E.; Nakauma-González, J. Alberto; Boormans, Joost; Junker, Kerstin; Hartmann, Arndt; Grünwald, Viktor; Hölzel, Michael; Eckstein, Markus (2024-04-24)
      <strong>PURPOSE</strong> The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet ...

    • TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies 

      Kalanithy, Jeshurun C.; Mingardo, Enrico; Stegmann, Jil D.; Dhakar, Ramgopal; Dakal, Tikam Chand; Rosenfeld, Jill A.; Tan, Wen-Hann; Coury, Stephanie A.; Woerner, Audrey C.; Sebastian, Jessica; Levy, Paul A.; Fleming, Leah R.; Waffenschmidt, Lea; Lindenberg, Tobias T.; Yilmaz, Öznur; Channab, Khadija; Babra, Bimaljeet K.; Christ, Andrea; Eiberger, Britta; Hölzel, Selina; Vidic, Clara; Häberlein, Felix; Ishorst, Nina; Rodriguez-Gatica, Juan E.; Pezeshkpoor, Behnaz; Kupczyk, Patrick A.; Vanakker, Olivier M.; Loddo, Sara; Novelli, Antonio; Dentici, Maria L.; Becker, Albert; Thiele, Holger; Posey, Jennifer E.; Lupski, James R.; Hilger, Alina C.; Reutter, Heiko M.; Merz, Waltraut M.; Dworschak, Gabriel C.; Odermatt, Benjamin (2024-12-23)
      <strong>Background</strong> Previous studies in mouse, <em>Xenopus</em> and zebrafish embryos show strong <em>tfap2e</em> expression in progenitor cells of neuronal and neural crest tissues suggesting its involvement in ...

    • Enemy or ally? Fasting as an essential regulator of immune responses 

      Wilhelm, Christoph; Surendar, Jayagopi; Karagiannis, Fotios (2021-04-14)
      Nutrition is essential for supplying an organism with sufficient energy to maintain its bodily functions. Apart from serving as an energy supply, the immunomodulatory effects of diet are emerging as a central aspect of ...