Institute: Browsing Institute by Title

Now showing items 1-20 of 51

    • 33/m: Komplettierung des Impfstatus vor Praktikum in Kindertagesstätte: Vorbereitung auf die Facharztprüfung: Fall 52 

      Dehnen, Dorothea; Reinsdorff, Melanie; Weltermann, Birgitta (2024-07-11)
      <strong>Prüfungssimulation</strong><br /> <strong><em>Fallschilderung</strong></em><br /> Ein 33-jähriger Student des Fachs Kindheitspädagogik möchte in 6 Wochen sein erstes Praktikum in einer Kindertagesstätte ...

    • Acceptability of surgical care in Uganda: a qualitative study on users and providers 

      Rauschendorf, Paula; Nume, Rosette; Bruchhausen, Walter (2023-07-31)
      <strong>Objectives</strong> This study was conducted to assess acceptability of surgical care in Eastern Uganda and enable better allocation of resources, and to guide health policy towards increased surgical care seeking.<br ...

    • Arterial Blood Supply of the Stifle Joint in Horses 

      Schöpper, Hanna; Egerbacher, Monika (2024-04-24)
      The vascularization pattern of the equine stifle joint is insufficiently described in the literature, even though there is a growing need for knowledge of the exact blood supply, as (i) arthroscopy and endoscopic surgery ...

    • Associations between COVID-19 Pandemic-Related Overtime, Perceived Chronic Stress and Burnout Symptoms in German General Practitioners and Practice Personnel: A Prospective Study 

      Küppers, Lucas; Göbel, Julian; Aretz, Benjamin; Rieger, Monika A.; Weltermann, Birgitta (2024-02-16)
      Background: The mental burdens of general practitioners (GPs) and practice assistants (PrAs) during the COVID-19 pandemic are well investigated. Work-related conditions like overtime are known to contribute to perceived ...

    • Barriers and Facilitators of Patient Engagement Activities to Improve Patient Safety in Healthcare Organizations: A Delphi-Based Expert Survey 

      Koch, Amelie; Brust, Larissa; Weigl, Matthias (2024-12-19)
      <strong>Purpose:</strong> In order to obtain sustainable healthcare, engagement of patients in patient safety improvement is vital. Drawing upon a multi-perspective approach, this study aimed to investigate perspectives ...

    • Bidirectional Effect of Long-Term Δ9‑Tetrahydrocannabinol Treatment on mTOR Activity and Metabolome 

      Bilkei-Gorzo, Andras; Schurmann, Britta; Schneider, Marion; Kraemer, Michael; Nidadavolu, Prakash; Beins, Eva C.; Müller, Christa E.; Dvir-Ginzberg, Mona; Zimmer, Andreas (2024-08-14)
      Brain aging is associated with cognitive decline, reduced synaptic plasticity, and altered metabolism. The activity of mechanistic target of rapamycin (mTOR) has a major impact on aging by regulating cellular metabolism. ...

    • Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function 

      Khani, Sajjad; Topel, Hande; Kardinal, Ronja; Tavanez, Ana Rita; Josephrajan, Ajeetha; Larsen, Bjørk Ditlev Marcher; Gaudry, Michael James; Leyendecker, Philipp; Meincke Egedal, Nadia; Güller, Aylin Seren; Stanic, Natasa; Ruppert, Phillip M. M.; Gaziano, Isabella; Hansmeier, Nils Rouven; Schmidt, Elena; Klemm, Paul; Vagliano, Lara-Marie; Stahl, Rainer; Duthie, Fraser; Krause, Jens-Henning; Bici, Ana; Engelhard, Christoph Andreas; Gohlke, Sabrina; Frommolt, Peter; Gnad, Thorsten; Rada-Iglesias, Alvaro; Pradas-Juni, Marta; Schulz, Tim Julius; Wunderlich, Frank Thomas; Pfeifer, Alexander; Bartelt, Alexander; Jastroch, Martin; Wachten, Dagmar; Kornfeld, Jan-Wilhelm (2024-04-29)
      Promoting brown adipose tissue (BAT) activity innovatively targetsobesity and metabolic disease. While thermogenic activation of BAT is wellunderstood, the rheostatic regulation of BAT to avoid excessive energy dissipation ...

    • Comorbidity profiles among sputum-positive tuberculosis patients in Cameroon 

      Magha, Chefor; Nchang, Lucy Cho; Weldeslassie, Michael; Nkimbeng, Desmond Akumtoh; Tchatat, Nancielle Mbiatong; Meriki, Henry Dilonga; Deribe, Kebede; Nietcho, Frank Noel; Foyet, Juluis Visnel; Fombad, Fanny Fri; Katcho, Tatiana Djikeussi; Fru Cho, Jerome; Gebremeskel, Eyoab Iyasu; Waddell, Simon J.; Bobosha, Kidist; Newport, Melanie J.; Hoerauf, Achim; Ritter, Manuel; Wanji, Samuel (2024-10-02)
      <strong>Introduction:</strong> Comorbid non-communicable diseases (NCDs) like diabetes, cardiovascular diseases (CVD), kidney diseases, and hypertension, could have implications for tuberculosis (TB) treatment management ...

    • Comparative development of human filariae Loa loa, Onchocerca volvulus and Mansonella perstans in immunocompromised mouse strains 

      Chunda, Valerine C.; Fombad, Fanny Fri; Kien, Chi Anizette; Ebai, Rene; Esofi, Frederick; Ntuh, Anna Ning; Ouam, Emmanuel; Gandjui, Narcisse Victor Tchamatchoua; Ekanya, Relindis; Nietcho, Franck; Nchang, Lucy Cho; Magha, Chefor; Njouendou, Abdel Jelil; Enyong, Peter; Hoerauf, Achim; Wanji, Samuel; Ritter, Manuel (2024-04-15)
      <strong>Introduction:</strong> Mouse models of human filarial infections are not only urgently needed to investigate the biology of the nematodes and their modulation of the host's immunity, but will also provide a platform ...

    • Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors 

      Klausen, Christina; Kaiser, Fabian; Stüven, Birthe; Hansen, Jan N.; Wachten, Dagmar (2019-11-14)
      The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ...

    • In vitro extracellular replication of Wolbachia endobacteria 

      Behrmann, Lara Vanessa; Meier, Kirstin; Vollmer, Jennifer; Chiedu, Chukwuebuka Chibuzo; Schiefer, Andrea; Hoerauf, Achim; Pfarr, Kenneth (2024-07-18)
      Obligate intracellular endobacteria of the genus <em>Wolbachia</em> are widespread in arthropods and several filarial nematodes. Control programs for vector-borne diseases (dengue, Zika, malaria) and anti-filarial therapy ...

    • NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer 

      Klümper, Niklas; Tran, Ngoc Khanh; Zschäbitz, Stefanie; Hahn, Oliver; Büttner, Thomas; Roghmann, Florian; Bolenz, Christian; Zengerling, Friedemann; Schwab, Constantin; Nagy, Dora; Toma, Marieta; Kristiansen, Glen; Heers, Hendrik; Ivanyi, Philipp; Niegisch, Günter; Grunewald, Camilla Marisa; Darr, Christopher; Farid, Arian; Schlack, Katrin; Abbas, Mahmoud; Aydogdu, Can; Casuscelli, Jozefina; Mokry, Theresa; Mayr, Michael; Niedersüß-Beke, Dora; Rausch, Steffen; Dietrich, Dimo; Saal, Jonas; Ellinger, Jörg; Ritter, Manuel; Alajati, Abdullah; Kuppe, Christoph; Meeks, Joshua; Vera Badillo, Francisco E.; Nakauma-González, J. Alberto; Boormans, Joost; Junker, Kerstin; Hartmann, Arndt; Grünwald, Viktor; Hölzel, Michael; Eckstein, Markus (2024-04-24)
      <strong>PURPOSE</strong> The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet ...

    • TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies 

      Kalanithy, Jeshurun C.; Mingardo, Enrico; Stegmann, Jil D.; Dhakar, Ramgopal; Dakal, Tikam Chand; Rosenfeld, Jill A.; Tan, Wen-Hann; Coury, Stephanie A.; Woerner, Audrey C.; Sebastian, Jessica; Levy, Paul A.; Fleming, Leah R.; Waffenschmidt, Lea; Lindenberg, Tobias T.; Yilmaz, Öznur; Channab, Khadija; Babra, Bimaljeet K.; Christ, Andrea; Eiberger, Britta; Hölzel, Selina; Vidic, Clara; Häberlein, Felix; Ishorst, Nina; Rodriguez-Gatica, Juan E.; Pezeshkpoor, Behnaz; Kupczyk, Patrick A.; Vanakker, Olivier M.; Loddo, Sara; Novelli, Antonio; Dentici, Maria L.; Becker, Albert; Thiele, Holger; Posey, Jennifer E.; Lupski, James R.; Hilger, Alina C.; Reutter, Heiko M.; Merz, Waltraut M.; Dworschak, Gabriel C.; Odermatt, Benjamin (2024-12-23)
      <strong>Background</strong> Previous studies in mouse, <em>Xenopus</em> and zebrafish embryos show strong <em>tfap2e</em> expression in progenitor cells of neuronal and neural crest tissues suggesting its involvement in ...

    • Enemy or ally? Fasting as an essential regulator of immune responses 

      Wilhelm, Christoph; Surendar, Jayagopi; Karagiannis, Fotios (2021-04-14)
      Nutrition is essential for supplying an organism with sufficient energy to maintain its bodily functions. Apart from serving as an energy supply, the immunomodulatory effects of diet are emerging as a central aspect of ...

    • Epidemiology and outcomes of vancomycin-resistant enterococcus infections: A systematic review and meta-analysis 

      Eichel, Vanessa M.; Last, Katharina; Brühwasser, Christina; Baum, Heike von; Dettenkofer, Markus; Götting, Tim; Grundmann, Hajo; Güldenhöven, Hanna; Liese, Jan; Martin, Maria; Papan, Cihan; Sadaghiani, Catharina; Wendt, Constanze; Werner, Guido; Mutters, Nico (2023-09-19)
      Vancomycin-resistant enterococci (VRE) cause many infections in the healthcare context. Knowledge regarding the epidemiology and burden of VRE infections, however, remains fragmented. We aimed to summarize recent studies ...

    • Evaluating AI Courses: A Valid and Reliable Instrument for Assessing Artificial-Intelligence Learning through Comparative Self-Assessment 

      Laupichler, Matthias Carl; Aster, Alexandra; Perschewski, Jan-Ole; Schleiss, Johannes (2023-09-26)
      A growing number of courses seek to increase the basic artificial-intelligence skills ("AI literacy") of their participants. At this time, there is no valid and reliable measurement tool that can be used to assess AI-learning ...

    • Exploring the Applicability of General Dietary Recommendations for People Affected by Obesity 

      Marsall, Matthias; Engelmann, Gerrit; Teufel, Martin; Bäuerle, Alexander (2023-03-25)
      (1) Obesity has emerged as a major public health challenge with increasing prevalence globally. The General Dietary Behavior Inventory (GDBI) was developed based on official dietary recommendations. However, little is known ...

    • Extracellular vesicles derived from Hepatitis-D Virus infected cells induce a proinflammatory cytokine response in human peripheral blood mononuclear cells and macrophages 

      Jung, Stephanie; Altstetter, Sebastian Maximilian; Wilsch, Florian; Shein, Mikhail; Schütz, Anne Kathrin; Protzer, Ulrike (2020-02-14)
      Hepatitis D Virus (HDV) is a satellite virus requiring a Hepatitis B Virus (HBV) envelope proteins for productive infection. Hepatitis D is the most severe form of viral hepatitis and is a global health threat affecting ...

    • Fate mapping reveals compartment-specific clonal expansion of mononuclear phagocytes during kidney disease 

      Yin, Junping; Mei, Qi; Prinz, Marco; Abdullah, Zeinab; Panzer, Ulf; Li, Jian; von Vietinghoff, Sibylle; Kurts, Christian (2023-06-07)

    • German GPs’ Self-Perceived Role in the COVID-19 Pandemic: Leadership, Participation in Regional Services and Preferences for Future Pandemic Preparedness 

      Kugai, Simon; Wild, Dorothea; Krumpholtz, Yelda; Schmidt, Manuela; Balzer, Katrin; Mayerböck, Astrid; Weltermann, Birgitta (2023-06-09)
      General practitioners (GPs) played a vital role during the COVID-19 pandemic. Little is known about GPs’ view of their role, leadership, participation in regional services and preferences for future pandemic preparedness. ...