Institute: Browsing Institute by Issue Date
Now showing items 1-11 of 11
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How to control cyclic nucleotide signaling by light
Jansen, Vera; Jikeli, Jan F.; Wachten, Dagmar (2017-03-10)Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has ... -
Shedding light on the role of cAMP in mammalian sperm physiology
Balbach, Melanie; Beckert, Vera; Hansen, Jan N.; Wachten, Dagmar (2018-06-15)Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the second messenger cAMP (cyclic adenosine monophosphate). In recent ... -
Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors
Klausen, Christina; Kaiser, Fabian; Stüven, Birthe; Hansen, Jan N.; Wachten, Dagmar (2019-11-14)The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ... -
Extracellular vesicles derived from Hepatitis-D Virus infected cells induce a proinflammatory cytokine response in human peripheral blood mononuclear cells and macrophages
Jung, Stephanie; Altstetter, Sebastian Maximilian; Wilsch, Florian; Shein, Mikhail; Schütz, Anne Kathrin; Protzer, Ulrike (2020-02-14)Hepatitis D Virus (HDV) is a satellite virus requiring a Hepatitis B Virus (HBV) envelope proteins for productive infection. Hepatitis D is the most severe form of viral hepatitis and is a global health threat affecting ... -
Intervertebral Disc and Adipokine Leptin—Loves Me, Loves Me Not
Curic, Goran (2020-12-31)Leptin—the most famous adipose tissue-secreted hormone—in the human body is mostly observed in a negative connotation, as the hormone level increases with the accumulation of body fat. Nowadays, fatness is becoming another ... -
Job Satisfaction and Chronic Stress of General Practitioners and Their Teams: Baseline Data of a Cluster-Randomised Trial (IMPROVEjob)
Degen, Lukas; Linden, Karen; Seifried-Dübon, Tanja; Werners, Brigitte; Grot, Matthias; Rind, Esther; Pieper, Claudia; Eilerts, Anna-Lisa; Schroeder, Verena; Kasten, Stefanie; Schmidt, Manuela; Goebel, Julian; Rieger, Monika A.; Weltermann, Birgitta M.; On Behalf Of The IMPROVEjob Consortium (2021-09-08)Background: A high prevalence of poor job satisfaction and high chronic stress is documented for general practitioners (GPs) and non-physician practice staff from various countries. The reasons are multifactorial ... -
Mini Review: Forensic Value of Aquaporines
Prangenberg, Julian; Doberentz, Elke; Madea, Burkhard (2021-12-17)Forensic pathologists are routinely confronted with unclear causes of death or findings. In some scenarios, it can be difficult to answer the specific questions posed by criminal investigators or prosecutors. Such scenarios ... -
Mini Review: The Forensic Value of Heat Shock Proteins
Prangenberg, Julian; Doberentz, Elke; Mawick, Anthea; Madea, Burkhard (2022-01-10)Forensic pathologists are routinely confronted with unclear causes of death or related findings. In some instances, difficulties arise in relation to questions posed by criminal investigators or prosecutors. Such scenarios ... -
Primary cilia and their effects on immune cell functions and metabolism: a model
Picon-Galindo, Ernesto; Latz, Eicke; Wachten, Dagmar (2022-05)Primary cilia are hair-like protrusions of the plasma membrane that function as cellular antennae and are present on most cells in the human body. Primary cilia dysfunction leads to severe diseases, commonly termed ... -
Small Changes in Patient Arrival and Consultation Times Have Large Effects on Patients' Waiting Times: Simulation Analyses for Primary Care
Grot, Matthias; Kugai, Simon; Degen, Lukas; Wiemer, Isabel; Werners, Brigitte; Weltermann, Birgitta (2023-01-18)(1) Background: Workflows are a daily challenge in general practices. The desired smooth work processes and patient flows are not easy to achieve. This study uses an operational research approach to illustrate the general ... -
Exploring the Applicability of General Dietary Recommendations for People Affected by Obesity
Marsall, Matthias; Engelmann, Gerrit; Teufel, Martin; Bäuerle, Alexander (2023-03-25)(1) Obesity has emerged as a major public health challenge with increasing prevalence globally. The General Dietary Behavior Inventory (GDBI) was developed based on official dietary recommendations. However, little is known ...