E-Dissertationen: Auflistung E-Dissertationen nach Titel
Anzeige der Dokumente 1746-1765 von 4074
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Identifizierung und Charakterisierung neuer Zielgene des Sonic Hedgehog/Patched-Signaltransduktionswegs in cerebellären Körnerzellprogenitoren der Maus und in humanen Medulloblastomen
(2004)Zellen bedienen sich so genannter Signaltransduktionskaskaden, um mit ihrer Umwelt zu kommunizieren. Abhängig vom Zelltyp reguliert der Sonic Hedgehog-Patched (Shh/Ptc)-Signalweg Prozesse wie Zellschicksalsbestimmung oder ... -
Identifizierung und Charakterisierung von Interaktionspartnern des Transkriptionsfaktors AATF
(2003)Der Transkriptionsfaktor AATF (<i>Apoptosis Antagonizing Transcription Factor</i>) wurde als Interaktionspartner der Dlk/ZIP-Kinase und der RNA-Polymerase II identifiziert. Zudem interagiert AATF mit dem Retinoblastomaprotein, ... -
Identifizierung und quantitative Bestimmung des Plasmavolumenexpanders Dextran und des Diuretikums Mannitol in Humanurin mittels Flüssigkeitschromatographie / Massenspektrometrie und Gaschromatographie / Massenspektrometrie zu Dopingkontrollzwecken
(2006)Gegenstand der vorliegenden Arbeit war die Entwicklung empfindlicher Nachweismethoden zur Bestimmung des Plasmavolumenexpanders Dextran und des Diuretikums Mannitol in Humanurin zu Dopingkontrollzwecken. Die Anwendung ... -
Identifizierung, Klonierung und heterologe Expression eines Terpensynthasegens aus Marrubium vulgare L.
(2002)Terpene gehören zu einer der größten und vielseitigsten Familien der Naturstoffprodukte. Neben wenigen Primärmetaboliten sind in dieser Familie hauptsächlich Sekundärmetaboliten, die größtenteils an Interaktionen zwischen ... -
Identifying Genetic Basis and Molecular Mechanisms in Different Types of von Willebrand Disease (VWD)
(2013-08-22)Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It is caused by quantitative or qualitative defects of the von Willebrand factor (VWF) which has crucial roles in hemostasis. VWD is classified ... -
Identifying intracellular cisplatin interaction partners and assessing their contribution to cisplatin resistance
(2016-10-24)Intracellular binding of cisplatin to non-DNA partners, such as proteins, has received increasing attention as an additional mode of action as well as a mechanism of resistance. In this project three cisplatin-interacting ... -
Image-Based Approaches to Hair Modeling
(2013-06-06)Hair is a relevant characteristic of virtual characters, therefore the modeling of plausible facial hair and hairstyles is an essential step in the generation of computer generated (CG) avatars. However, the inherent ... -
Imaging a life span: In vivo Magnetic Resonance Imaging of Development and Ageing in Rat and Mouse Brain
(2016-01-28)Rats and mice are the most abundantly used animal models in translational research. They are employed in the service of clinical research in the sense of establishing methods, testing therapeutic strategies and pharmacological ... -
Imaging Meningiomas: The Road to the First Medical Application of the Novel Magnetic Resonance Rheology
(2017-04-25)In this thesis the first application of Magnetic Resonance Rheology (MRR) to patients with known brain lesions was presented.<br /> MRR is a novel approach to image the mechanical properties of brain tissue in vivo. It ... -
Imaging Outside The Box: Enhancing the Performance and Applicability of Time-of-Flight Sensors through Computational Sensing
(2022-12-12)Time-of-Flight (ToF) imaging, which allows to measure the time that light has taken to travel from a light source to a camera, is an increasingly relevant sensing modality. ToF imagers are used, for example, in smartphones, ... -
Immune modifying effect of drug free PLGA nanoparticles on the course of experimental autoimmune neuritis (EAN)
(2024-03-15)Experimental autoimmune neuritis (EAN) animal model mimics the human Guillain-Barre syndrome (GBS), an autoimmune disease of demyelination and inflammation of peripheral nerves. Despite advancement in clinical management ... -
Immune modulation by experimental filarial infection and its impact on E. coli-induced sepsis
(2015-11-12)Helminths cause so-called neglected tropical diseases in tropical and sub-tropical regions and are prevalent in almost one third of mankind. Thus, co-infections of helminths with other pathogens are common. However, the ... -
Immune regulation in Plasmodium berghei ANKA infected mice either lacking type I interferon signalling or mimicking malaria tolerance
(2017-03-16)Malaria is a disease caused by <em>Plasmodium</em> parasites and transmitted by female <em>Anopheles</em> mosquitoes. Children under the age of five, pregnant women and none-immune individuals are at risk of developing ... -
Immune Regulation in Human Filariasis
(2013-03-14)Vector transmitted diseases such as the tropical helminth infections onchocerciasis and lymphatic filariasis (LF) affect more than 150 million people worldwide and are both considered major public health concerns. In order ... -
The immunomodulatory capacity of helminths on inflammation: Impact of eosinophils on E. coli-induced sepsis and genome-wide transcriptome profiling of human monocytes stimulated with helminth extract and LPS implicate immune functions and diseases
(2017-10-19)Human filarial nematode infections cause lymphatic filariasis and onchocerciasis in more than 150 million people worldwide. An infection can result in debilitating clinical manifestations like visual impairment or lymphedema ... -
Immunregulation durch alternative Antigenpräsentation am Beispiel der HCV- und HIV-Infektion
(2011-01-28)Das nicht-klassische MHC-I Molekül HLA-E spielt eine bedeutende Rolle bei der Regulation der NK-Zell-vermittelten Zytotoxizität und der zytotoxischen CD8(+) T-Zellantwort. Im Gegensatz zu klassischen MHC-I Molekülen ist ... -
Immuntoxinproduktion in Pflanzen: Eine innovative Methode zur Herstellung neuartiger Therapeutika gegen das Hodgkin Lymphom
(2006)Immuntoxine bergen ein großes Potenzial in der Therapie des Hodgkin Lymphoms. Als Zielantigene können hier CD25 und CD30 gewählt werden, welche beide auf den entarteten Reed-Sternberg-Zellen überexprimiert werden. Die ... -
Impact and Range Extension of Invasive Foraminifera in the NW Mediterranean Sea: Implications for Diversity and Ecosystem Functioning
(2018-01-18)Climate warming and the poleward widening of the tropical belt have induced range shifts in a variety of marine and terrestrial organisms. Among the key taxa that are rapidly expanding their latitudinal range are larger ... -
The impact and underlying molecular mechanisms of cell adhesion molecules integrins and syndecans in the cisplatin chemoresistance of melanoma cells
(2019-12-06)Cancer is a complex, but also devastating disease, which today, more than ever, is present in our lives and society. Practically every person has a close relative or friend, or has been themselves affected by this disease. ... -
Impact assessment of global change on wetland-catchment interactions in a tropical East African catchment
(2020-02-27)Water is the key to sustainable development, especially in sub-Saharan Africa (SSA), where a large part of the population lives on subsistence farming. Reliable knowledge of available water resources therefore is an ...
