E-Dissertationen: Auflistung E-Dissertationen nach Autor "Famulok, Michael"
Anzeige der Dokumente 1-20 von 31
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Aptamerselektion zur Funktionsuntersuchung von zytosolischen Proteinen
Fucik, Katharina (2007)Zur biologischen Einordnung der CC-bindenden Proteine CYTIP und KIAA0403 einem auf Genomebene neu entdeckten Vertreter, wie auch FHL2, einem vielseitigen Ko-Transkriptionsfaktor, wurde die Aptamertechnologie zur in vitro ... -
Aufbau von DNA-Nanoarchitekturen mittels funktionalisierter DNA-Bausteine
Rasched, Goran Gerhard G. (2007)Es existiert ein wachsendes Interesse an neuen Materialien und Methoden, die für den „Bottom-up“-Ansatz zur Erzeugung von höher geordneten zwei- und dreidimensionalen Strukturen im Nanometermaßstab geeignet sind. Nucleinsäuren ... -
Binding of cytohesin 2 to the plasma membrane and its relationship with the EGFR
Karnowski, Nora (2018-11-06)Eukaryotic cells are compartmentalized by lipid membranes to achieve the spatial separation of biological processes and signaling pathways. Controlled trafficking of proteins between these compartments as well as the ... -
Biochemical and structural studies of the interaction between ARNO and the Epidermal Growth Factor Receptor
Weiche, Benjamin Felix Crispin (2014-09-18)Receptor tyrosine kinases (RTKs) and small GTP binding proteins (GTPases) are essential regulators of multiple cellular processes, making a tight control of their activity crucial for cellular homeostasis. Recently, it was ... -
Biophysical analysis of protein-protein and protein-small molecule interactions
Albertoni, Barbara (2011-11-29)The validation of small molecule inhibitors identified by high throughput screening requires a set of robust assays for interaction analysis. Here I describe the implementation of three methods: bioluminescence resonance ... -
Biophysical studies of EGFR conformation and interaction
Yin, Dongsheng (2019-03-26)Epidermal growth factor receptor (EGFR) plays such a crucial role in cell signaling that its activity is intricately regulated. According to the prevailing activation model, EGF binding to EGFR initiates a series of ... -
Charakterisierung des CPEB3 Ribozyms: Studien zur Aufklärung des Mechanismus eines humanen Ribozyms
Kulikov, Katharina (2019-03-27)Kurze RNA Stränge mit enzymatischer Aktivität sind als Ribozyme bekannt. Das HDV-ähnliche CPEB3 Ribozym ist eine wenig erforschte selbstspaltende RNA. Es existiert in einer einzelnen hochkonservierten Kopie in der Sequenz ... -
Chemical modulation of guanine nucleotide exchange factor activity: A small molecule inhibitor for the Rabex-5 mediated Rab5 activation
Wosnitza, Christine Irene (2013-09-02)The small GTPase Rab5 is a key regulator in the early endocytic pathway. The activity of Rab5 is controlled by numerous guanine nucleotide exchange factors (GEFs), which catalyse the exchange of GDP for GTP. However, the ... -
Chemisch modifizierte Aptamere: Eine Werkzeugkiste der Chemischen Biologie
Rohrbach, Friedrich Falk (2014-07-03)In der klinischen Diagnostik besteht ein großes Interesse an verlässlichen Systemen zur kostengünstigen Quantifizierung von Biomarkern. Im Falle eines Enzyms als Zielmolekül ist neben der Messung der Menge auch die Bestimmung ... -
Cytohesins are cytoplasmic ErbB receptor activators
Bill, Anke (2011-07-12)Signaling by ErbB receptors requires the activation of their cytoplasmic tyrosine kinase domains which is initiated by ligand binding to the receptor ectodomains. Up to now, cytoplasmic factors contributing to the activation ... -
Design, Assembly and Triggering of Interlocked DNA Nanoarchitectures
Lohmann, Finn (2015-09-25)Interlocked molecular systems are well known in supramolecular chemistry and are widely used for various applications like sensors, molecular machines and logic gates. However, these systems present some drawbacks, as the ... -
Design, assembly, and operation of a self-regulating DNA rotaxane linear actuator
Yu, Ze (2022-04-07)DNA is not only the carrier of genetic information but also an excellent bottom-up material for constructing nanostructures due to its high degree of programmability. Interlocked DNA nanostructures have a potential use as ... -
Entwicklung neuer Therapiekonzepte im myxoiden Liposarkom: Die Rolle von Fibroblastenwachstumsfaktor-Rezeptoren und microRNAs
Pasternack, Helen Sarah (2016-04-21)Myxoide Liposarkome gehören zu den häufigsten Weichgewebssarkomen. Ihre Pathogenese ist aber bislang nur unvollständig verstanden und es stehen keine zielgerichteten Therapien zur Verfügung. Die für myxoide Liposarkome ... -
Expanding the toolbox of modified nucleobases and click chemistry for investigations on non-coding RNA
Domnick, Christof (2019-05-20)Non-coding ribonucleic acid (RNA) consists of highly structured molecules whose arrangement and function can be investigated using different chemical labeling approaches. Contemporary labeling techniques show restrictions ... -
Functional investigation of cannabinoid receptors
Date, Rahul Anant (2008)The endocannabinoid system performs various regulatory functions and has been implicated in a growing number of physiological roles. In an animal model for cutaneous contact hypersensitivity (CHS), we show that mice lacking ... -
Functionalization of nucleic acids using an expanded genetic alphabet
Eggert, Frank (2020-02-06)RNA performs key functions on all levels of life including coding, regulation, and catalysis. These characteristics crucially depend on sensitive three-dimensional structure development.
Functional engineering ... -
High Throughput Screening and mRNA-Display Selection for the Identification of Biologically Functional Molecules
Yamazaki, Satoko (2006)Biologically functional molecules with desired properties have proven to be invaluable tools for investigating biological systems. Moreover, the identification of those functional molecules is a crucial task in modern drug ... -
Identifizierung und Charakterisierung eines neuen Inhibitors der PH-Domäne der Cytohesin-Familie
Theis, Julian (2011-07-04)Die Pleckstrin-homologe Domäne (PH-Domäne), die in vielen Proteinen zu finden ist, ist durch ihre Interaktion mit Phosphoinositiden (z.B. PIP3) entscheidend an der Membranrekrutierung dieser Proteine beteiligt.
Die ... -
Inhibition von Cytohesinen führt zu hepatischer Insulinresistenz
Hafner, Markus (2007)G-Proteine sind eine wichtige Klasse von Regulatoren in allen lebenden Systemen. Sie werden durch Guanosinnukleotidaustauschfaktoren (GEFs) aktiviert, die den Austausch von GDP durch GTP katalysieren. Diese Aktivität macht ... -
Investigation of riboswitches as new antibacterial targets: Identification and characterization of novel synthetic and natural riboswitch modulators with effect on bacterial cell growth
Lünse, Christina E. (2013-01-24)The increase in bacterial resistances and the decrease in available antibacterial substances against multi-drug resistant pathogens calls for an intensified search for novel antibiotics. Therefore, in this study riboswitches ...