E-Dissertationen: Suche
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Pseudomycoicidin, a novel lantibiotic produced by Bacillus pseudomycoides
(2014-09-12)
The continuous increase of antibiotic resistant pathogens necessitates a search for new antibiotics. In this study a novel lantibiotic gene cluster was identified using the publicly available genome database. Blast searches ......
Protein-protein interactions in human pluripotent stem cell-derived neural stem cells and their neuronal progeny
(2014-09-29)
While most approaches in cell-based disease modeling are focused on the effects of defined mutations on the molecular or cellular phenotype, the assessment of underlying alterations in the interactomes of disease-relevant ...
Untersuchungen zur antiviralen Aktivität des humanen Zinkfinger antiviralen Proteins gegen Alphaviren
(2014-09-11)
Das Zinkfinger antivirale Protein (ZAP) wurde als antiviraler Wirtsfaktor identifiziert, der die Replikation und Verbreitung verschiedener Viren inhibiert. In der vorliegenden Arbeit wurde die antivirale Aktivität der ...
Intrazerebroventrikuläre Enzymersatztherapie der metachromatischen Leukodystrophie
(2014-09-25)
Die metachromatische Leukodystrophie (MLD) ist eine autosomal rezessiv vererbte lysosomale Speicherkrankheit. Diese wird durch einen Gendefekt der Arylsulfatase A (ASA) verursacht, welche den ersten Schritt in der Degradation ......
Consequence of FA2H Deficiency and FA2H Interaction Partners Revealed by Proteomic Analyses
(2015-03-10)
Fatty acid-2 hydroxylase (FA2H) is a 43 kDa transmembrane protein residing in the endoplasmic reticulum. As a monooxygenase it is responsible for the alpha–hydroxylation of fatty acids, which are later incorporated into ...
RNA aptamers as selective protein kinase inhibitors: New molecular tools for the elucidation of signal transduction pathways
(2015-04-16)
Elucidating the precise function of individual protein kinases within complex signal transduction cascades represents one of the greatest challenges in molecular biology. Protein kinases are enzymes that catalyze the ...
Genetics of schizophrenia: Contribution of rare and low-frequency sequence variants in selected genomic regions to disease susceptibility
(2015-03-27)
Schizophrenia is a highly heritable, multifactorial mental disorder. Up to date, a number of common SNPs with low penetrance and large rare structural variants (CNVs) with higher penetrance have been identified to contribute ......
Investigating the molecular mechanism of the anti-inflammatory effects of HDL in macrophages
(2015-03-17)
Inflammation is critical for clearing microbial infections, however, excessive or pro-longed inflammation is an underlying component of many disease states, including atherosclerosis. Macrophages recognise sterile or ......
Tetraspanin web formation and function
(2015-03-13)
The cell membrane is crucial for living cells; it encloses the intracellular matrix, maintains the concentration of cytosolic components, and controls the in-/outward signalling and interaction pathways. The cell membrane ...
The role of T helper 17 cells in the Pathogenesis of Human Onchocerciasis
(2015-03-31)
Onchocerciasis, also known as river blindness, is a tropical disease causing health and socioeconomic problems in endemic communities, especially sub-Saharan Africa. The disease is elicited by a filarial parasite called ......