E-Dissertationen: Suche
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Biophysical analysis of protein-protein and protein-small molecule interactions
(2011-11-29)
The validation of small molecule inhibitors identified by high throughput screening requires a set of robust assays for interaction analysis. Here I describe the implementation of three methods: bioluminescence resonance ...
Revealing the Mechanism of Thiopeptide Antibiotics at Atomistic Resolution: Implications for Rational Drug Design
(2012-07-18)
For decades drug design has primarily focused on small molecules that bind to well-formed tight binding pockets, such as the catalytic centers of enzymes. Recently, there is increasing interest to design compounds that ...
Analyses of Adhesion Topography and Fluctuations in Bio-Membranes by Advanced Optical Microscopy
(2012-05-21)
The cell membrane not only mechanically separates the interior of the cell from the exterior environment but is also an active organelle involved in a host of functions like maintaining osmotic balance, aiding in ...
Etablierung eines praxisnahen Prüfverfahrens für chemische Desinfektionsverfahren zur Wirksamkeit gegenüber Trinkwasserbiofilmen: Wirksamkeitsprüfung chemischer Desinfektionsverfahren im Silikonschlauchmodell
(2011-04-04)
Viele Mikroorganismen können sich in Biofilmen organisieren. 95% der im Wasser vorkommenden Mikroorganismen befinden sich in Trinkwasserbiofilmen. Dieser bietet durch seine geringe Durchlässigkeit einen erhöhten Schutz vor ...
Novel Secondary Metabolites from Endophytic Marine-derived Fungi
(2011-02-22)
The marine environment is distinguished by unique groups of organisms being the source of a wide array of fascinating structures. Marine microorganisms, such as fungi often occur associated with macroorganisms like algae, ...
Kraftkopplung in Zellen
(2011-07-28)
In dieser Arbeit wird zum ersten Mal gezeigt, wie durch Verformung eines elastischen Substrates, Kraft in Zellen übertragen werden kann und an welchen Punkten diese Kraft in Zellen übertragen wird. Da sich eine eingeleitete ...
Bispidin-Derivate als neue nicotinische Acetylcholinrezeptor-Liganden: Synthese, In-vitro-Pharmakologie und Struktur-Wirkungsbeziehungen
(2009-10-29)
Nicotinische Acetylcholinrezeptoren (nAChR) sind ligandgesteuerte Ionenkänale, die sich aus fünf Untereinheiten zusammensetzen. Durch die Kombination verschiedener Untereinheiten (α1-α10, β1-β4, γ, δ ε) entstehen zahlreiche ......
Bispidine Derivatives as Novel Ligands for the Nicotinic Acetylcholine Receptors : Synthesis, In vitro Pharmacology and Structure-Activity Relationships
Nicotinic acetylcholine receptors (nAChRs) are ......
Bispidine Derivatives as Novel Ligands for the Nicotinic Acetylcholine Receptors : Synthesis, In vitro Pharmacology and Structure-Activity Relationships
Nicotinic acetylcholine receptors (nAChRs) are ......
Methods for Computer-Aided Chemical Biology: Exploration of Compound Selectivity
(2009-07-03)
Computational drug design and discovery methods have traditionally put much emphasis on the identification of novel active compounds and the optimization of their potency. For chemical genetics and genomics applications, ...
Cell-cell adhesion mediated by mobile receptor-ligand pairs: a biomimetic study
(2009-05-07)
This thesis aims at a quantitative understanding of the physical processes in cell-cell adhesion caused by mobile cell adhesion molecules. To unequivocally separate physical processes from active biological cell response, ...
Biochemical and functional analysis of innexin2-containing gap junction channels during organogenesis in Drosophila
(2009-05-13)
Gap junctions channels serve as mediators for direct cell-to cell communication between cells of different tissues and organs by the exchange of small metabolites and signalling molecules. They are formed by analogous ...