E-Dissertationen: Search
Now showing items 2171-2180 of 2282
Establishment of a cell-based anti-prion compound screen and analysis of host response to prion infection in cerebellar organotypic slice cultures
(2019-02-19)
Prions are unconventional infectious agents that cause always fatal neurodegenerative diseases termed prion disease or transmissible spongiform encephalopathies in mammals. Prion diseases are caused by an accumulation of ......
Site-Directed Spin Labeling of Large Riboswitches Using Click Chemistry
(2019-02-14)
Due to the conformational variability of riboswitches, their structural analysis is of a great importance. The most frequently used techniques to investigate dynamic processes within the riboswitches are NMR and FRET. EPR ...
Sparse representation of multivariate functions based on discrete point evaluations
(2019-01-22)
Functions provide one of the most important building blocks for model descriptions of reality. Central point of this thesis is the approximation of multivariate functions using Faber-Schauder hat functions. In the first ...
Formation mechanisms and aroma potential of 2-aminoacetophenone in boar fat
(2019-03-21)
For decades the surgical castration of male piglets has been a common practice to avoid the incidence of boar taint within Europe. Boar taint is known as an offensive off-flavour occurring when meat of uncastrated boars ...
In situ observations of reaction and transport phenomena during silicate glass corrosion by fluid-cell Raman spectroscopy: Method development and applications
(2020-07-06)
Borosilicate glass is the preferred material for the immobilization of high-level nuclear waste and an important material for various industries. Silicate glasses, however, are prone to corrosion by aqueous solutions, which ......
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
Numerical investigations of heat and mass transport in fractured porous rock masses
(2019-01-08)
Fluid flow processes in the subsurface are accompanied by heat and mass transport with several important feedbacks including reactive flow, and precipitation/dissolution processes. Heat and mass transport through fractured ...
Effects of Mitochondrial Nucleases on mtDNA Degradation
(2019-01-11)
Mitochondria are unique to have a multicopy genome, resulting in a substantially different fate of damaged DNA molecules in comparison to nuclear DNA. Damaged DNA usually represents only a small fraction of total mitochondrial ...
Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments
(2019-01-18)
The cumulative doctoral thesis "Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments" deals with the application of stable isotopes for structure elucidation ...
Formulierung von therapeutischen Oligonukleotiden mit PAMAM-Dendrimeren zur Aktivierung von Pattern Recognition Rezeptoren des angeborenen Immunsystems
(2019-05-03)
Der ubiquitär exprimierte Immunrezeptor Retinoic Acid inducible Gene-I, kurz RIG-I, ist eine zytosolisch lokalisierte Helikase, die zur Detektion von pathogenen RNA-Viren befähigt ist. Als synthetischer Ligand konnte eine ......