E-Dissertationen: Search
Now showing items 221-230 of 255
Investigation of Phthalazine, Quinazoline and Pyrimidine Derivatives as ABCG2 Inhibitors
(2018-08-28)
Globally, cancer is the second leading cause of death. Chemotherapy is commonly used in the treatment of cancer. However, in clinic, a wide variety of cancers display resistance to chemotherapy leading to the failure of ...
The role of the endocannabinoid receptor CB2 in a mouse model of Alzheimer's disease
(2018-09-26)
Over the past years, an important role of the cannabinoid receptor 2 (CB2) has been implicated in several neurological and immunological conditions, such as experimental autoimmune encephalitis, stroke, memory, neuropathic ......
Therapeutic effects of wetlands on mental well-being: The concept of therapeutic landscapes applied to an ecosystem in Uganda
(2018-07-03)
The therapeutic effects of wetlands help to keep people mentally healthy. Especially in developing countries, health care prioritizes the treatment and prevention of physical illness before mental illness due to the high ...
Untersuchungen zum Metabolismus und Nachweisfenster von γ-Hydroxybuttersäure in biologischem Material
(2018-03-19)
In dieser Arbeit wurden interdisziplinäre Untersuchungen durchgeführt, um die Nachweisbarkeitsdauer nach einer Gamma-Hydroxybuttersäure-(GHB)-Gabe in biologischen Matrices zu verlängern. Es sollten biologische Marker ...
Fast detection of protein-protein interactions with an automated FRET-based system on the flow cytometer
(2018-03-12)
Although protein-protein interactions play a major role in almost all biological functions, those interactions cannot easily be analysed, especially not on single cell level and with regard to dynamic changes in protein ...
Lipide als Transport- und Signalmoleküle: Untersuchungen in Makrophagen und Neuronen
(2018-04-17)
Lipide haben einen großen Anwendungsbereich und speziell in der Biochemie des lebenden Organismus wichtige Funktionen. Neben ihrer hauptsächlichen Funktion als Energiespeicher und Strukturkomponenten der Zellmembranen ...
The importance of endogenous opioids in feeding behavior
(2018-03-14)
Endogenous opioids are involved in a broadly distributed neural network regulating eating behavior. Opioid transmission has long been implicated in controlling hedonic and homeostatic feeding as well as regulating body ......
Functional cooperation of Toll-like receptor signaling and the high-affinity receptor for IgE, FcεRI, on human Langerhans cells
(2018-01-15)
Atopic dermatitis (AD) is a multifactorial severe skin disease with increasing incidence in western countries. In the disease, Langerhans cells (LC) play a pivotal role in bridging innate and adaptive immunity through ......
The endophytic fungus Stemphylium globuliferum – secondary metabolites and biological activities
(2018-01-22)
Fungi are a tremendous source of pharmaceutically significant compounds, e.g. the life saving immunosuppressant drug mycophenolic acid. The current project focused on the investigation of the mold fungus Stemphylium ......
Cisplatin resistance is associated with altered signalling in NSCLC cells
(2018-01-18)
The efficacy of cisplatin-based chemotherapy in cancer is limited by the occurrence of innate and acquired drug resistance. In order to better understand the mechanisms underlying acquired cisplatin resistance, the ...