E-Dissertationen: Search
Now showing items 241-250 of 255
Identification of novel TAM receptor interacting proteins: Screening for novel ligands
(2019-02-07)
The TAM receptors TYRO3, AXL, and MER are well characterized for their roles in cell proliferation and survival, phagocytosis, and inhibition of inflammation. The complexities of these TAM receptor responses imply a level ...
Charakterisierung des CPEB3 Ribozyms: Studien zur Aufklärung des Mechanismus eines humanen Ribozyms
(2019-03-27)
Kurze RNA Stränge mit enzymatischer Aktivität sind als Ribozyme bekannt. Das HDV-ähnliche CPEB3 Ribozym ist eine wenig erforschte selbstspaltende RNA. Es existiert in einer einzelnen hochkonservierten Kopie in der Sequenz ...
Empfehlungen zur sicheren Anwendung von Arzneimitteln im Off-Label-Use in Deutschland
(2019-02-19)
Unter einem Off-Label-Use wird die Anwendung von Fertigarzneimitteln verstanden, die entsprechend dem Arzneimittelgesetz in Verkehr gebracht wurden, aber außerhalb des in der nationalen oder (de)zentralen Zulassung definierten ...
Protein and epigenetic biomarkers for variability in epidermal growth factor receptor inhibition in cancer treatment and characterization of the inhibitor-induced skin toxicity in an in vitro model
(2019-01-31)
Epidermal growth factor receptor (EGFR) is often over-expressed or over-activated in cells of solid tumors and can be targeted by specific inhibitors (EGFRIs), like erlotinib, gefitinib, cetuximab and panitumumab. ...
Effects of Mitochondrial Nucleases on mtDNA Degradation
(2019-01-11)
Mitochondria are unique to have a multicopy genome, resulting in a substantially different fate of damaged DNA molecules in comparison to nuclear DNA. Damaged DNA usually represents only a small fraction of total mitochondrial ...
Formulierung von therapeutischen Oligonukleotiden mit PAMAM-Dendrimeren zur Aktivierung von Pattern Recognition Rezeptoren des angeborenen Immunsystems
(2019-05-03)
Der ubiquitär exprimierte Immunrezeptor Retinoic Acid inducible Gene-I, kurz RIG-I, ist eine zytosolisch lokalisierte Helikase, die zur Detektion von pathogenen RNA-Viren befähigt ist. Als synthetischer Ligand konnte eine ......
Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry
(2019-06-21)
Compound promiscuity offers both opportunities and perils for medicinal chemistry and drug discovery. On the one hand, it is well-established that compounds elicit their therapeutic potential by engaging with multiple ...
Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
(2019-06-05)
Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for the synthesis of ......
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...