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Totalsynthese von Archazolid F und Strukturanaloga
(2018-09-28)
In dieser Arbeit werden synthetische Studien zur Totalsynthese von Archazolid F und biologisch aktiven Strukturanaloga vorgestellt. Seit ihrer Isolierung spielten die Archazolide eine wichtige Rolle in der Erforschung der ...
Constructive Approximation and Learning by Greedy Algorithms
(2018-09-06)
This thesis develops several kernel-based greedy algorithms for different machine learning problems and analyzes their theoretical and empirical properties. Greedy approaches have been extensively used in the past for ...
A participatory multi-criteria approach for flood vulnerability assessment
(2018-09-14)
The management of flood risk calls for a better understanding of vulnerability, as hazards only become disasters if they impact a system that is vulnerable to their effects. Although different frameworks have been proposed ...
Alternatives Spleißen von BAG6 verändert die Zytoskelett-Architektur und die epithelial-mesenchymale- Transition in humanen Zellen
(2018-10-12)
Das menschliche Genom gewinnt durch alternatives Spleißen an zellulärer Proteinkomplexi-tät. Für mehrere Vertreter der BAG-Proteinfamilie sind bisher Spleißvarianten bekannt, die sich in ihrer Wirkung auf die zelluläre ...
The role of cytohesins and the ARNO-CNK1 complex in insulin signalling
(2018-09-26)
The tight regulation of signalling cascades is of crucial importance for organisms in order to react to external stimuli and maintain homeostasis. Insulin signalling is a key metabolic pathway in vertebrates and dysregulation ......
On some variational problems in geometry
(2018-08-28)
In this thesis we consider several variational problems in geometry that have a connection to the spectrum of the Laplacian acting on functions. In the first part, we study a quantity called the analytic systole, which was ...
Magnetic Quantum Walks of Neutral Atoms in Optical Lattices
(2018-09-17)
This thesis focuses on the simulation of the physics of a charged particle under an external magnetic field by using discrete-time quantum walks of a spin-1/2 particle in a two-dimensional lattice. By Floquet-engineering ...
Ectopic expression of the sialic acid modifying enzyme CMAH in human THP1 macrophages
(2018-09-03)
Throughout evolutionary processes, organisms gain or lose functions because of emerging mutations. The frameshift mutation emerged in the human CMAH gene is one of these loss of function mutations and it caused the human ...
Synthese, Eigenschaften und Anwendung von Squarainen als Komponente in Photodioden
(2018-11-23)
Die Eigenschaften organischer Halbleiterbauteile werden in großem Maße von der Morphologie des organischen Materials bestimmt. Das Verständnis und die gezielte Kontrolle der Morphologie sind somit unabdingbar bei der ...
Crystal chemistry, melt composition and redox controls on the behavior of trace elements during lunar magmatism
(2018-12-12)
The behavior of trace elements in magmatic systems is controlled by physicochemical conditions prevalent during mantle partial melting and magmatic differentiation. Among these controlling factors are temperature, depth, ...