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Role of IgG4-mediated Suppression of Immune Effector Mechanisms in Human Filariasis
Prodjinotho, Ulrich Fabien (2017-03-15)Lymphatic filariasis (LF) is a major public health concern in tropical and subtropical countries. The infection affects more than 120 million people and has significant social and economic consequences on affected individuals ... -
The role of innate lymphoid cells in liver disease: Identification of a hepatic IL-13-producing ILC3-like population potentially involved in liver fibrosis
Raabe, Jan (2022-05-23)Innate lymphoid cells (ILCs) are a family of innate immune cells that mirror the functionality of T lymphocytes but do not express rearranged antigen receptors. As tissue-resident cells, ILCs primarily reside in peripheral ... -
Role of innate lymphoid cells in type 1-dominated experimental Plasmodium berghei ANKA and type 2-dominated Litomosoides sigmodontis infection
Reichwald, Julia Jennifer (2021-10-27)Malaria and filariasis remain among the biggest health problems in the tropics and subtropics, especially in Africa, and in the case of malaria among the ten most frequent causes of death. The parasites that cause malaria ... -
The Role of Inosine in Adipose Tissue Metabolism
Niemann, Birte (2022-05-02)During the last decades, obesity has become a pandemic disease, associated with severe comorbidities, and a major problem for health care systems. Obesity results from energy imbalance, when energy intake exceeds energy ... -
The role of inositol pyrophosphates in the regulation of plant stress responses
Lange, Esther (2023-07-13)Inositol polyphosphates (InsPs) have been described as important messengers in eukaryotic cells. InsPs with one or more diphospho groups are also termed inositol pyrophosphates (PP-InsPs), which gained special attention ... -
Role of interleukin-6 during infection with the filarial nematode Litomosoides sigmodontis
Muhsin (2013-12-04)Lymphatic filariasis is a neglected tropical disease that is caused by parasitic helminths and affects 120 million people worldwide, while 1.3 billion people live in endemic areas. Three species of tissue dwelling nematodes ... -
The Role of Job Changes in Sustainable Return to Work for Breast Cancer Survivors – Patterns of Interpretation and Coping Strategies
Hiltrop, Kati Sigrid (2022-01-06)Thus far, research on return to work (RTW) after breast cancer has focused on objective outcomes such as return rates. Moreover, a strong emphasis on the initial RTW can be observed in the literature. However, knowledge ... -
The role of linear energy transfer in modulating radiationinduced NF-κB activation and its down-stream target genes
Chishti, Arif Ali (2014-07-23)To enable long-term human spaceflight, the cellular radiation response to heavy ions with a high linear energy transfer (LET) needs to be better understood for developing appropriate countermeasures to mitigate acute effects ... -
The Role of Lipids in the Formation of Beneficial Interactions Between Plant Roots and Soil Microbiota under Heat Stress
Macabuhay, Allene Andaya (2024-07-15)Climate change, which is characterized by the rise of global atmospheric temperatures known as global warming, has serious detrimental effects on crop production because of the direct influence of elevated temperature on ... -
The role of local agroforestry practices for enhancing food and nutrition security of smallholding farming households: The case of Yayu area, south-western Ethiopia
Jemal, Omarsherif Mohammed (2018-08-15)When agriculture becomes focused on globally traded commodities, local nutrition may be at risk. The study tested this hypothesis in the coffee landscape of Yayu, south-west Ethiopia, by investigating the role of local ... -
The role of loneliness in the neurocognitive processing of psychosocial stress and trauma
Morr, Mitjan (2023-08-17)Loneliness is a ubiquitous problem in modern societies due to its detrimental psychological and physiological health effects. Loneliness is closely associated with psychosocial stress, a link further exacerbating mental ... -
Role of long-range CA3 connectivity in linking spatial and aversive information
Nikbakht, Negar (2022-04-12)The CA3 region of the hippocampus is an auto-associative network that is thought to enable rapid associations between spatial locations and non-spatial information. As such, it is important for retention and retrieval of ... -
The role of mass movements for slope evolution: conceptual approaches and model applications in the Bonn area
Schmidt, Jochen (2001)Understanding slope processes and slope systems in different timescales is focused by a range of approaches from different disciplines. This work is based on a multi-disciplinary research approach within the project SFB350 ... -
Role of Maternal Dengue Virus Antibodies in the Development of Congenital Zika Syndrome
Feldmann, Marie (2022-05-16)The Zika virus (ZIKV) epidemic and sharp increase in the number of microcephaly cases in the Americas in 2015-2016 led to the documentation of congenital zika syndrome (CZS) in children born to mothers who were infected ... -
Role of membrane lipids in regulation of Alzheimer’s disease associated proteins and vice-a-versa
Tamboli, Irfan Yunus (2008)Alzheimer’s disease (AD) is associated with extracellular deposits of the amyloid β- peptide (Aβ) and intraneuronal aggregates of hyperphosphorylated tau protein in the brain. Aβ is generated by sequential proteolytic ... -
The Role of microRNAs in the Regulation of Human UDP-glucuronosyltransferases (UGTs)
Paulusch, Stefan (2021-06-14)The liver is involved in endo- and xenobiotic metabolism due to the expression of drug-metabolizing UDP-glucuronosyltransferases (UGTs). By UGT-mediated elimination of hazardous compounds and other reactive metabolites, ... -
The Role of Modern Audio-Visual Media in the Construction of Iranian National Identity
Abbasian, Kaveh (2021-06-08)This paper sheds light on a less explored aspect of the modern construction of Iranian national identity. It investigates the role of modern audio-visual media including cinema, radio and television in this modern construction. ... -
The role of MyD88-dependent signaling pathways in skin mast cells in UVB-induced skin diseases
Majlesain, Yasmin (2022-03-04)Excessive UV irradiation is a major risk factor for health. While chronic long-term UV exposure induces skin aging and suppression of the immune system, acute UV exposure leads to skin inflammation, also known as sunburn. ... -
The Role of NMDA Receptor Co-Agonists in Dendritic Integration
Bohmbach, Kirsten (2021-03-26)The integration of synaptic inputs is the fundamental function of neurons. This integration does not only take place at the soma, but also dendrites can actively shape the input-output computations of a neuronal network. ... -
Role of Pathogenic Mediators in murine Arthritis and Levels of Serum Soluble CD21 and CD23 in autoimmune patients
Singh, Anjana (2009-03-23)Importance of the nervous system in immune regulation is clearly suggested by innervations of lymphoid tissues by sympathetic nerve fibers. We determined the role of sympathetic, parasympathetic and peripheral nervous ...