E-Dissertationen: Suche
Anzeige der Dokumente 161-170 von 218
Dissecting patient heterogeneity via statistical modeling based on multi-modal omics data
(2019-06-27)
One of the key goals of modern medicine is to treat patients individually, recognizing the heterogeneity that exists within them and thus hoping to provide them with more effective personalized therapies. '-Omics' patient ...
Untersuchungen zur Biogenese des Protoanemonins
(2019-06-25)
Verschiedene potentielle C-14 markierte Precursor wurden an Helleborus foetidus Pflanzen appliziert. Durch Wasserdampfdestillation wurde Protoanemonin gewonnen, durch Aufarbeitung mittels verdünnter Salzsäure wurden andere ...
Small-scale Physical and Chemical Structure of Diffuse and Translucent Molecular Clouds along the Line of Sight to the Galactic Center
(2019-05-02)
Diffuse and translucent molecular clouds constitute a large part of the molecular interstellar medium (ISM) in our Galaxy as well as in other spiral galaxies. In particular, the envelopes of giant molecular clouds (GMCs), ...
From C-phosphanylated thiazole-2-thiones to phosphaalkenes and tricyclic 1,4-diphosphinines
(2019-05-15)
The PhD Thesis “From C-phosphanylated thiazole-2-thiones to phosphaalkenes and tricyclic 1,4-diphosphinines” describes investigations on the synthesis of thiazolyl substituted phosphaalkenes, tricyclic 1,4-dihydro-1,4-di ...
Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
(2019-06-05)
Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for the synthesis of ......
Search for charged lepton-flavour violation in top-quark decays at the LHC with the ATLAS detector
(2019-09-06)
A direct search for charged lepton-flavour violation in top-quark decays is presented. The data analysed correspond to 79.8 fb-1 of proton-proton collisions at a centre-of-mass energy of √s = 13 TeV delivered ......
Fortschritte bei der Totalsynthese von Lysolipin I: Studien zur Synthese des Südfragments
(2019-05-27)
Die vorliegende Doktorarbeit behandelt die Totalsynthese des aromatischen Polyketids Lysolipin I (1), einem potenten Antibiotikum aus dem Bakterium Streptomyces violaceoniger mit hoch modifizierten und einzigartigen ...
A Dispositional Perspective of Resilience and Power: An Application of Power Asymmetries in Farming Communities in Caroni, Trinidad and Tobago
(2019-06-04)
Global change processes such as climate change and its impact on food systems, coastal communities and small island states requires us to rethink how sustainable development can be achieved in these coupled environments. ...
Mass spectrometric investigations of intermediates from organic reactions using electrospray ionization
(2019-06-07)
This thesis focuses on strategies for the mechanistic investigation of organic reactions using electrospray mass spectrometry (ESI-MS). The results of mass spectrometric studies on an organocatalytic aldol reaction as well ...
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...