The Faculty of Medicine: Medizinische Fakultät: Recent submissions
Now showing items 101-120 of 2126
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Molekulargenetische Verfahren zur Untersuchung der Patienten- und Umgebungsmikrobiom-assoziierten Krankheitsentstehung und -dynamik
(2025-07-18)Die präsentierten Ergebnisse unterstreichen die Bedeutung des Mikrobioms nicht nur als Indikator für gesundheitliche Zustände, sondern auch als aktiven Teilnehmer in der Krankheitsentwicklung. Durch die detaillierte Analyse ... -
Attention Deficit Hyperactivity Disorder: A Risk Factor for Premature Discontinuation of Inpatient Opioid Withdrawal Treatment
(2024-06-03)<strong>Background:</strong> Substance use disorders present a tremendous challenge within contemporary healthcare systems. Specifically, in the domain of opioid use disorders (OUDs), several foundational elements are ... -
Severe autoimmune hemolytic anemia following immunotherapy with checkpoint inhibitors in two patients with metastatic melanoma: a case report
(2024-03-20)<strong>Introduction:</strong> Over the past decade, immune checkpoint inhibitors such as antibodies against cytotoxicity T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have become ... -
Comparative development of human filariae Loa loa, Onchocerca volvulus and Mansonella perstans in immunocompromised mouse strains
(2024-04-15)<strong>Introduction:</strong> Mouse models of human filarial infections are not only urgently needed to investigate the biology of the nematodes and their modulation of the host's immunity, but will also provide a platform ... -
The unusual mode of action of the polyketide glycoside antibiotic cervimycin C
(2024-05-09)Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by <em>Streptomyces tendae</em> HKI 0179 with bactericidal activity against Gram-positive bacteria. In this study, cervimycin C (CmC) treatment caused a ... -
The role of dendritic cells in MASH: friends or foes?
(2024-04-08)Dendritic cells (DCs) are major antigen-presenting cells that connect innate and adaptive immunity. Hepatic DCs are less activated and contribute to maintain the tolerogenic environment of the liver under steady state. ... -
Generation of a Generic Nanobody-based CAR-T Cell Platform
(2025-07-16)Recent advances in cancer therapy, particularly immune checkpoint blockade (ICB), have significantly improved immune responses against tumors. However, many patients do not respond to ICB, and some experience disease ... -
Entwicklung der Morbidität und Komorbidität in einem kardiologischen Reha-Setting von 2006 bis 2019: Eine unizentrische Studie
(2025-07-15)Einleitung / Problemstellung<br /> Die klinische Beobachtung zeigte, dass Veränderungen in der Akutmedizin langfristig auch zu Auswirkungen in der kardiologischen Rehabilitation führten. Systematische Untersuchungen zu ... -
Das Manchester Triage System in der Anwendung bei Patienten mit Schwindel: Eine wissenschaftliche Untersuchung zur Genauigkeit in der Zentralen Notaufnahme
(2025-07-15)Schwindel zählt zu den häufigsten Beschwerden, mit denen Patienten in die Notaufnahme kommen und kann zahlreiche Ursachen haben – von harmlosen Funktionsstörungen des Vestibularorgans bis hin zu zeitkritischen, lebensbedrohlichen ... -
The role of cysteines and S-palmitoylation in NLRP3 inflammasome activation
(2025-07-15)Nucleotide oligomerization domain (NOD)-like receptor protein 3 (NLRP3) is a cytosolic pattern recognition receptor with a critical role in numerous autoinflammatory disorders and non-communicable diseases characterized ... -
Schlaganfallwissen von Patient*innen mit Hypertonie: Eine Sekundärdatenanalyse von Daten der PIA-Studie
(2025-07-14)Die arterielle Hypertonie zählt zu den Hauptrisikofaktoren für die Entwicklung eines Schlaganfalls. Sowohl in der Primär- als auch in der Sekundärprävention ist die Senkung eines erhöhten Blutdruckes essentiell zur ... -
Inhibition of gap junctions as a novel treatment strategy for medulloblastoma
(2025-07-14)The discovery of communicative cellular networks has reshaped our understanding of brain tumor biology. Despite the growing knowledge of Cx43-based GJ as key drivers of malignant intercellular connectivity in several ... -
Precision and limits of human vision: How visual resolution depends on ocular optics and spatiotemporal sampling characteristics of the foveolar photoreceptor mosaic
(2025-07-11)The human ability to perceive fine spatial details, known as visual resolution, requires combined capacities of both the eye and the brain. Research in anatomy, physiology, and psychophysics has extensively studied the ... -
Untersuchung des Menopausenalters und anderer fertilitätsreduzierender Faktoren bei 167 Lynch-Syndrom-Patientinnen
(2025-07-11)Das Lynch Syndrom ist eines der häufigsten monogen erblichen Tumorsyndrome. Ursächlich sind heterozygote pathogene Keimbahnvarianten in einem der vier DNA-Missmatch-Reparatur-Gene (<em>MLH1</em>, <em>MSH2</em>, <em>MSH6</em> ... -
Pluripotent stem cells as a model system for the investigation of cardiovascular development and disease
(2025-07-11)Cardiovascular diseases account for 32% of total worldwide mortality, according to the World Health Organization (WHO), thus underscoring the need for innovative therapeutic approaches. The pluripotency characteristic of ... -
Leveraging prime editing to model the impact of oncogenic signalling on melanoma plasticity
(2025-07-09)(noch nicht zugänglich / not yet accessible) -
Investigating the Impact of LncRNAs PUNISHER and GAS5 on the Pathogenesis of Calcific Aortic Valve Disease
(2025-07-09)Calcific aortic valve disease (CAVD) is a progressive disorder marked by fibrosis and calcification of the aortic valve, lacking effective pharmacological treatment. This study investigates the roles of two long non-coding ... -
Klinisches Ergebnis der mehrfragmentären Claviculafrakturen in Abhängigkeit der operativen Versorgung (Plattenosteosynthese Vs. Intramedulläre Drahtosteosynthese)
(2025-07-08)<strong>Hintergrund:</strong> Mittelschaftfrakturen der Clavicula sind die häufigsten Frakturformen der Clavicula und repräsentieren 80% aller Claviculafrakturen. Bei den dislozierten Frakturen der Clavicula bringt die ... -
Advances in tree-based regression for modeling biomedical data
(2025-07-08)Health-related research questions require methods that can deal with the growing complexity and dimensionality of biomedical data sets. A popular alternative to common parametric regression approaches are tree-based models, ... -
Modulating Tumor Promotion by Targeting Inflammation and Endoplasmic Reticulum Stress
(2025-07-08)<strong>Background:</strong> Inflammation and ER stress are two prominent hallmarks of tumors, both exhibiting distinct dual roles in tumor promotion. The duration and intensity of inflammation and ER stress can drive ...
