E-Dissertationen: Suche
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Re-modelling of Mitochondrial Respiration in Arabidopsis during Drought
(2019-03-20)
Drought can severely limit growth and productivity of plants. To limit water loss by transpiration, plant leaves respond by reducing stomatal aperture. This simultaneously impairs CO2 uptake and can reduce carbon ......
Trockenheit kann das Wachstum und die Produktivität von Pflanzen stark einschränken. Pflanzen können den Wasserverlust durch Transpiration über die Spaltöffnungen in den Blättern regulieren und somit minimieren. Dies ......
Trockenheit kann das Wachstum und die Produktivität von Pflanzen stark einschränken. Pflanzen können den Wasserverlust durch Transpiration über die Spaltöffnungen in den Blättern regulieren und somit minimieren. Dies ......
Zebrafish as a Model Organism to Study the In Vivo Role of G-Protein Coupled Receptor 17 in Myelination
(2019-02-26)
The sheathing of axons with myelin by oligodendrocytes constitutes a necessity for sufficient and rapid nerve conduction within the vertebrate central nervous system (CNS). However to date, the complex molecular mechanisms ...
Ein neuer Weg der mikrobiellen Schwefeloxidation: Das Heterodisulfidreduktase-ähnliche System
(2019-01-31)
Heterodisulfidreduktase-Komplexe vom ABC-Typ koppeln in methanogenen Archaeen durch eine Flavin-basierte Elektronen-Bifurkation die endergone Reduktion von Ferredoxin mit der exergonen Reduktion von CoM-S-S-CoB. Hdr-ähnliche ......
Genome mining of marine bacteria for bioactive metabolites
(2019-02-04)
Marine bacteria have come into the focus for natural product discovery as a consequence of the emergence of antibiotic resistance. This was additionally boosted by the limitations encountered in drug developments from ...
Characterization of regulatory T cells in atopic dermatitis
(2019-02-05)
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases with increasing incidence. It has been suggested that Tregs play a role in the pathogenesis of AD, as Tregs regulate immune homeostasis ......
Establishment of a cell-based anti-prion compound screen and analysis of host response to prion infection in cerebellar organotypic slice cultures
(2019-02-19)
Prions are unconventional infectious agents that cause always fatal neurodegenerative diseases termed prion disease or transmissible spongiform encephalopathies in mammals. Prion diseases are caused by an accumulation of ......
Effects of Mitochondrial Nucleases on mtDNA Degradation
(2019-01-11)
Mitochondria are unique to have a multicopy genome, resulting in a substantially different fate of damaged DNA molecules in comparison to nuclear DNA. Damaged DNA usually represents only a small fraction of total mitochondrial ...
Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments
(2019-01-18)
The cumulative doctoral thesis "Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments" deals with the application of stable isotopes for structure elucidation ...
Bioinformatische und in-vitro-Analyse der frs-Biosynthesegencluster von Cand. Burkholderia crenata und Chromobacterium vaccinii
(2019-07-03)
FR900359 (FR) ist ein selektiver Gq-Proteininhibitor, der ursprünglich aus der Pflanze Ardisia crenata isoliert wurde. G-Proteine spielen eine zentrale Rolle in der Signalübertragung von G-Protein ......
Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry
(2019-06-21)
Compound promiscuity offers both opportunities and perils for medicinal chemistry and drug discovery. On the one hand, it is well-established that compounds elicit their therapeutic potential by engaging with multiple ...