E-Dissertationen: Search
Now showing items 921-930 of 1173
Molecular Mechanisms in the Unconventional Secretion of Insulin-Degrading Enzyme
(2018-04-12)
Extracellular deposition of amyloid-ß (Aß) plaques in the brain, a hallmark of Alzheimer’s disease (AD), results from an imbalance between production and clearance of the peptide. Insulin-degrading enzyme (IDE) is one of ...
Study of infection induced alteration in Drosophila larval feeding behavior
(2018-03-27)
Decision making ability is a key trait that can increase an organism’s chances of survival. The animal has to constantly analyze its environment and modulate ones behavior to navigate through daily routine. This study aims ...
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
(2018-06-04)
The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ...
Complement-mediated neuronal loss by sialic acid glycocalyx alterations
(2018-04-23)
Every neuronal cell is covered with a dense structure of glycoconjugates, the glycocalyx. Sialic acids form the terminal ends of the glycocalyx and thus, are more accessible for the cellular environment. Microglia, the ...
Regulation of gene expression in specific mouse brain cells during neurodegenerative prion disease
(2018-05-24)
Why neurodegenerative diseases target specific brain regions is poorly understood. We hypothesize that this selective vulnerability is caused by specific brain cells in these regions having unique strategies and capacities ...
Interaktionen und Signalweiterleitung von Dectin-1 in dendritischen, tolerogenen dendritischen Zellen sowie Transfektionsmodellen
(2018-06-06)
Dectin-1 ist ein Musterkennungrezeptor auf Zellen des Immunsystem, welcher beta-Glukane in der Zellwand von pathogenen Pilzen erkennen und über Sykvermittelte Signalwege sowohl Mechanismen des angeborenen, als auch des ......
Dectin-1 is a pattern-recognition receptor on cells of the immune system, which recognizes beta-glucans in the cell wall of pathogenic fungi and subsequently induces innate and adaptive immune responses via Syk-mediated ......
Dectin-1 is a pattern-recognition receptor on cells of the immune system, which recognizes beta-glucans in the cell wall of pathogenic fungi and subsequently induces innate and adaptive immune responses via Syk-mediated ......
The glmS ribozyme is an antibacterial target: Mode of action analysis, investigation of potential metabolite analogs and characterization of glmS ribozyme variants of human pathogens
(2018-05-22)
Bacteria increasingly develop resistances to the known antibiotics, this threatens human health. Thus, novel antibiotics are urgently needed. The currently used antibiotics mainly target five bacterial processes and are ...
From glycosidase activity profiling to inhibitor discovery in the plant pathogen Pseudomonas syringae
(2018-05-25)
Retaining glycosidases are important in plants for various biological processes. Plant genomes encode for more than 200 retaining glycosidases but the physiological roles and activities of many remain poorly understood. ...
Implementation and characterisation of click-SELEX targeting the chemokine CXCL9, for the development of a POC device for renal allograft rejection
(2021-11-04)
Renal allograft rejection is a serious medicinal condition, as appr. 25 % of the allografts are rejected. This medical disorder will lead to death of the patient if not treated early. Currently the gold standard to diagnose ...
Untersuchungen zur Erweiterung des Substratspektrums von Gluconobacter oxydans
(2018-01-29)
Die vorliegende Arbeit befasste sich mit einem bislang weitgehend unbearbeiteten Bereich der Stammoptimierung des biotechnologisch und industriell wichtigen Essigsäurebakteriums Gluconobacter oxydans. Dieser Organismus ist ......