Faculties of University Bonn: Fakultäten der Universität Bonn: Recent submissions
Now showing items 141-160 of 9517
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The role of RER1 in the assembly and transport of TREM2-DAP12 complex and cellular lipid metabolism
(2025-07-25)DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed on lymphoid and myeloid lineage cells, and interacts with several immune receptors to form functional complexes that trigger intracellular ... -
Modelling structure-function relationships from neurons to networks in the cerebral cortex
(2025-07-24)Using a multi-scale model based on extensive experimental data, I explored structure-function relationships in cortex. At a macro-scale, I used ANNs with cortical features to show that sparse connectivity enables efficient ... -
Stability and construction of negatively curved Einstein metrics
(2025-07-23)We prove several stability results for negatively curved Einstein metrics. The main applications of these results are: <br/> (1) The construction of infinitely many non-trivial closed Einstein manifolds with negative ... -
Targeting tumor cells with cytokine-induced killer cells and bifunctional peptides
(2025-07-23)Antimicrobial peptides have gained much attention in clinical research due to their extensive possibilities of application beyond antimicrobial use. The modification of antimicrobial peptides enables the peptides to target ... -
Perturbative and non-perturbative theories of structure formation
(2025-07-23)(noch nicht zugänglich / not yet accessible) -
Das Hitzeschockprotein GRP78 als Biomarker für Diagnose und Prognose bei Patienten mit Koronarer Herzerkrankung
(2025-07-23)Das Hitzeschockprotein Glucose-regulated-protein-78 (GRP78) hat einen entscheidenden Einfluss auf die Homöostase im endoplasmatischen Retikulum und ist maßgeblich an der Antwort auf Stress des endoplasmatischen Retikulums ... -
Metabolic Network Reconstruction of Algal Strains of Chlorella species
(2025-07-23)<em>Chlorella</em> is a photosynthetic, eukaryotic microalgae that has received profound interest as a prospective feed source for the production of biofuels. For efficient biotechnological application, the high light ... -
Exploring Suberin's Functionality in Roots, Shoots and Tubers: A Comparative Analysis
(2025-07-23)Suberization is a key plant process that forms hydrophobic barriers to regulate water loss and substance exchange. This thesis reviews the evolution of our understanding of suberin and related polymers like cutin and lignin, ... -
Sexuelle Missbrauchserlebnisse in Kindheit und Jugend: Offenbarungsverhalten Betroffener, Kontinuität der Erinnerungen und Fachkenntnisse in relevanten Berufsgruppen
(2025-07-23)Die Arbeit untersucht den Themenkomplex des Erinnerns und Offenbarens von sexuellem Missbrauch in Kindheit und Jugend sowie den Umgang mit Verdachtsfällen. In zwei retrospektiven Onlinestudien wurden Betroffene befragt, ... -
Synthetic diets exacerbate auto-immunity in mice: EAE stage resolved proteomic immune cell characterization
(2025-07-23)Western diet (WD)-associated non-communicable diseases (NCDs), including metabolic syndrome, and neurodegenerative conditions like multiple sclerosis (MS), are leading causes of death in the Western world. Although our ... -
Non-invasive physical plasma as an oncological therapy option: Modulation of cancer cell growth, motility, and metabolism without induction of cancer resistance factors
(2025-07-23)<strong>Background:</strong> Physical plasma, the fourth state of matter formed through gas ionization, has shown promise in various clinical applications, including wound healing and antimicrobial therapy. Recently, ... -
The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex
(2024-07-05)The prefrontal cortex (PFC) undergoes a protracted maturation process. This is true both for local interneurons and for innervation from midbrain dopaminergic (mDA) neurons. In the striatum, dopaminergic (DA) neurotransmission ... -
Demirjian's and Cameriere's Methods for the Assessment of Dental Age Estimation in Children from a Southern Brazilian City
(2024-07-13)The chronological age estimation of living individuals is a crucial part of forensic practice and clinical practice, such as in orthodontic treatment. It is well-known that methods for age estimation in living children ... -
Long-term seizure outcome after epilepsy surgery of neuroglial tumors
(2024-05-23)<strong>Purpose:</strong> Neuroglial tumors are frequently associated with pharmacorefractory epilepsies. However, comprehensive knowledge about long-term outcomes after epilepsy surgery and the main prognostic factors for ... -
The Gender Gap in Earnings Losses After Job Displacement
(2024-03-13)We compare men and women who are displaced from similar jobs by applying an event study design combined with propensity score matching and reweighting to administrative data from Germany. After a mass layoff, women's ... -
Linguistically Aware and Augmentation-Driven Methods for Enhancing Natural Language Understanding
(2025-07-22)Current large language models excel in solving numerous complicated tasks, but are primarily optimized for the English language and popular application domains, delivering sub-optimal outputs for low-resource languages and ... -
Gender, Gender (In)Equality, and Small-holder farming in Northern Ethiopia: Discourses and Practices
(2025-07-21)This research unravels the ways in which gender is understood, articulated, and enters into small holder farming in Ethiopia and how these conceptions, understandings, and articulations create and re-create a system of ... -
One-dimensional aggregates of the organic dye quinacridone on metallic and dielectric surfaces
(2025-07-21)The present work deals with the question to what extent the motif of intermolecular hydrogen bonds (H-bonds) can be used to generate isolated one-dimensional (1D) structures, i.e. "chains", of organic molecules on surfaces ... -
Regenerative Parodontalchirurgie und kieferorthopädische Zahnbewegung bei Stadium IV Parodontitis: Ergebnisse klinischer Studien
(2025-07-21)Parodontitis im Stadium IV ist charakterisiert durch schweren Verlust an parodontalem Attachment, vertikale Knochendefekte und pathologische Zahnwanderung (PTM). Die Komplexität des Krankheitsbildes aufgrund von PTM - ... -
Development of Histone Deacetylase Inhibitors and Degraders with Antiplasmodial and Anticancer Activity
(2025-07-21)Histone deacetylases (HDACs) are key targets in epigenetic drug discovery, as they catalyze the removal of acetyl and acyl groups from lysine side chains of histones and other proteins, thereby influencing gene expression ...
