Mathematisch-Naturwissenschaftliche Fakultät: eDissertationen
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Global Timing Optimization in Chip Design
(2021-04-12)In this thesis, we aim at solving the interconnect optimization problem comprehensively. By balancing global timing, routing, placement, and power constraints in a global model, we obtain solutions which outperform the ... -
Design, Synthesis and Structure-Activity-Relationships of Potent Mas-Related G Protein-Coupled Receptor X (MRGPRX) Modulators
(2021-04-12)(noch nicht zugänglich / not yet accessible) -
Investigation of the in vivo Lysosomal Proteome Changes in Different Starvation Periods
(2021-04-09)(noch nicht zugänglich / not yet accessible) -
The Influence of Solvent Reorganization on Organocatalytic Reactions
(2021-04-07)In the last decades N-heterocyclic carbenes have shown a certain potential as organocatalysts. In addition to the formation of regio- and stereoselective C-C coupling reactions, their scope of application includes the ... -
Approximate Inference Applications toRepresentation Learning and Stochastic ProcessesProblems
(2021-04-07)The present dissertation dwells in the development of inference algorithms and methodologies for the study of dynamical datasets. We developed techniques to analyze time-series datasets for point processes, switching ... -
Homological Stability, Characteristic Classes and the Minimal Genus Problem
(2021-04-07)The purpose of this thesis is to study the (co-)homological properties of the classifying space of subsurface bundles in a trivial background bundle with fiber a manifold M. We will investigate homological stability ... -
Long-timescale atomistic simulations
(2021-03-31)The simulation and analysis of particle systems dynamics is an important subfield of computational materials science. It allows the investigation of many properties of interest, such as reaction mechanisms, diffusion rates, ... -
Testing models of galaxy formation and evolution with galaxy-galaxy-galaxy lensing
(2021-03-29)Explaining the formation and evolution of galaxies is a fundamental issue in modern astronomy. Several competing models try to explain how galaxies form and predict the relationship between galaxies and dark matter. A ... -
Mechanism-based Stratification of Alzheimer's and Parkinson's Disease using Artificial Intelligence
(2021-03-29)The capacity to generate omics and clinical data in biomedical science is growing exponentially over the past decades. Additionally, recent advances in computational power and analyzing capabilities have resulted in ... -
Extremes of the discrete Gaussian free field in dimension two
(2021-03-26)In recent years, there have been many advances towards an understanding of the extreme value theory of log-correlated random fields. Log-correlated random fields are conjectured to compose a universality class ... -
The Role of NMDA Receptor Co-Agonists in Dendritic Integration
(2021-03-26)(noch nicht zugänglich / not yet accessible) -
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ... -
Behavioral Studies with IT-Administrators - Updating in Complex Environments and Securing Web Servers
(2021-03-25)Up until the turn of the millennium, research in the field of IT security mainly focused on the technical aspects of security mechanisms. Since then, the human factor has become more and more important and sparked research ... -
Formation and reactions of P-amino substituted Li/Cl phosphinidenoid complexes
(2021-03-25)In this PhD Thesis results on the synthesis of P-amino substituted Li/Cl phosphinidenoid complexes are presented, with a particular focus on their reactivity in polar and apolar solvents and characteristic trapping reactions ... -
Targeted Fast Radio Burst Searches with the Efflesberg 100-m Radio Telescope
(2021-03-24)Fast radio bursts (FRBs) are bright, energetic, millisecond duration radio bursts of extragalactic origin. The source of FRBs still remains an open problem. Since the discovery of FRBs in 2007, over 100 FRBs have been ... -
Schrumpfungsprozesse als zentrale Herausforderung für die zukünftige Entwicklung von Kommunen im Rahmen der rheinland-pfälzischen Dorferneuerung: dargestellt am Fallbeispiel des Landkreises Mayen-Koblenz
(2021-03-23)Die Herausforderungen und bislang zumeist unbekannten Änderungserfordernisse an bestehende Strukturen, welche sich aus den ablaufenden Prozessen des demographischen Wandels ergeben, sind die momentan gewichtigsten, welche ... -
Fundamental Studies of Adsorption Reactions in Organic Electrolytes and Electrocatalysis
(2021-03-18)Adsorption processes have a vital influence on the features of heterogeneous electrochemical systems, like processes in electric double-layer capacitors and fuel cell systems. In order to study the fundamentals of such ... -
Translatome analysis and in vivo Ca2+ imaging of astrocytes in an Alzheimer’s disease mouse model
(2021-03-18)(noch nicht zugänglich / not yet accessible) -
Identification of Intracellular Protein Binding Partners of Cisplatin and Their Role in Acquired and Intrinsic Resistance
(2021-03-18)Cisplatin is a widely used drug in treatment of various solid tumors, amongst others ovarian cancer. However, whereas acquired resistance significantly limits therapy success, some tumors such as colorectal cancer are ... -
Influence of the St. John's Wort Extract Ze117 on the Lipidome of PBMC and on the Lateral Diffusion of ß1-Adrenergic Receptors in C6 Cells
(2021-03-18)Stress causes pathological changes in the signal transduction of neurotransmitter systems, which can lead to depression. Signaling relies not only on receptor-ligand interactions and subsequent regulatory processes, but ...
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