The Faculty of Medicine: Medizinische Fakultät: Recent submissions
Now showing items 21-40 of 2281
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Passive Blood-Flow-Restriction Exercise's Impact on Muscle Atrophy Post-Total Knee Replacement: A Randomized Trial
Franz, Alexander; Heiß, Luisa; Schlotmann, Marie; Ji, Sanghyeon; Strauss, Andreas Christian; Randau, Thomas; Fröschen, Frank Sebastian (2025-07-23)<strong>Background/Objectives:</strong> Total knee arthroplasty (TKA) is commonly associated with postoperative muscle atrophy and weakness, while traditional rehabilitation is often limited by pain and patient compliance. ... -
FVIII Trafficking Dynamics Across Subcellular Organelles Using CRISPR/Cas9 Specific Gene Knockouts
El Hazzouri, Salime; Al-Rifai, Rawya; Surges, Nicole; Rath, Melanie; Singer, Heike; Oldenburg, Johannes; El-Maarri, Osman (2025-07-01)Factor VIII (FVIII) interacts with Endoplasmic Reticulum (ER) chaperones Calnexin (CANX) and Calreticulin (CALR) and with ER-Golgi Intermediate Compartment (ERGIC) transporters, Lectin, mannose-binding 1 (LMAN1) and Multiple ... -
In Vivo Antibiotic Elution and Inflammatory Response During Two-Stage Total Knee Arthroplasty Revision: A Microdialysis Pilot Study
Behrens, Julika Johanna; Franz, Alexander; Schildberg, Frank Alexander; Rudowitz, Markus; Grote, Stefan; Fröschen, Frank Sebastian (2025-07-24)<strong>Introduction: </strong>Two-stage revision with an antibiotic-loaded, temporary static cement spacer is a common treatment for periprosthetic joint infection (PJI) of the knee. However, limited data exists on in ... -
Peritonsillar abscess in children: A retrospective analysis on surgical and antimicrobial approaches
Rudhart, Stefan Alexander; Send, Thorsten; Tilk, Maike; Leggewie, Barbara; Bosse, Franziska; Eichhorn, Klaus; Strieth, Sebastian; Hoch, Stephan; Maas, Alexander Philippe (2025-07-07)<strong>Background</strong> <br/> Peritonsillar abscess (PTA) is a prevalent infection for specialists in otorhinolaryngology and pediatric primary care providers, that has the potential to cause severe complications. ... -
Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease
Karl, Rudolfo; Ashraf, Arsila Palliyulla Kariat; Viola, Maria Francesca; Hopp, Katharina; Mass, Elvira; Wachten, Dagmar (2025-08-26)Autosomal-dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized bymutations in <em>PKD1</em> or <em>PKD2</em>, which drive cystogenesis in renal epithelial cells. Immune cells, particularly macrophages, ... -
A multi-group path analysis of medication documentation quality using cross-sectional survey data: Impact of leadership, job satisfaction, patient-related burnout, and patient safety culture
Gambashidze, Nikoloz; Wagner, Anke; Manser, Tanja; Rieger, Monika A.; Martus, Peter; Hammer, Antje (2025-09-12)Medication-related adverse events are a major problem for patient safety and quality of care. This study explored the effects of leadership, job satisfaction, patient-related burnout and patient safety culture, measured ... -
Cognitive deficits in treatment-resistant depression: protocol for a systematic review and meta-analysis
Ronold, Eivind Haga; Jensen, Daniel; Thorsen, Anders Lillevik L.; Raudeberg, Rune; Oltedal, Leif; Hammar, Åsa; Hirnstein, Marco; Douglas, Katie; Porter, Richard; Kiebs, Maximilian (2025-07-03)<strong>Introduction</strong> Major depressive disorder (MDD) is a major global healthcare challenge. This is, in part, due to the lack of treatment response and chronic course of MDD. Such a course of illness is often ... -
Einfluss der lokalen HIFU-Behandlung auf das Überleben bei fortgeschrittenem Pankreaskarzinom
Boewe, Janik Wolfgang (2025-12-23)<strong>Hintergrund:</strong> Das Pankreaskarzinom ist eine hochaggressive maligne Erkrankung, die aufgrund eines häufig lange asymptomatischen Verlaufs meist erst in einem fortgeschrittenen, inoperablen Stadium diagnostiziert ... -
Standardized Evaluation of Chondrocyte Inflammation Model with TNF alpha
Wang, Su (2025-12-23)This study aimed to develop a standardized chondrocyte inflammation model by evaluating the effects of TNFα concentration and cell passage, and to further refine it into a dynamic model that more accurately reflects ... -
Das klinische Outcome von Acetabulumfrakturen: Kraftentwicklung, Lebensqualität und Bewegungsausmaß
Ben Amar, Soufian (2025-12-19)Acetabulumfrakturen sind selten, jedoch nehmen ihre Inzidenzen in den letzten Jahren, insbesondere bei geriatrischen Patienten, zu. Dies ist auf den demografischen Wandel und veränderte Lebensgewohnheiten zurückzuführen. ... -
Evaluation of personalized video gaming therapy in patients with depression - motivational, behavioral, and neuronal mechanisms
Bergmann, Moritz (2025-12-19)This thesis examines the efficacy of personalized video game-based cognitive training (VGT) as an adjunctive treatment in patients with Major Depressive Disorder (MDD), focusing on its motivational, behavioral, and neuronal ... -
Frühgeburtlichkeit und Hüftdysplasie: Eine retrospektive Fall-Kontrollstudie
Schütz, Leon (2025-12-19)Die primäre oder kongenitale Hüftdysplasie ist eine seltene Erkrankung, die bei etwa 2-4 % der Neugeborenen auftritt. Ohne adäquate Behandlung kann es bereits im frühen Erwachsenenalter zu arthrosebedingten Schmerzen und ... -
Lysosomale Proteine in der Biomarkerforschung: Systematische Analyse klinischer Relevanz und proteomischer Nachweisstrategien
Hackenberg, Yannic (2025-12-19)Lysosomale Proteine werden zunehmend als potenzielle Biomarker für zahlreiche Erkrankungen diskutiert, ihre zuverlässige Detektion in klinischen Proben stellt jedoch weiterhin eine analytische Herausforderung dar. In dieser ... -
Identification of novel mediators of T cell function in chronic infection and cancer
Heyden, Leonie (2025-12-17)Cytotoxic CD8<sup>+</sup> T cells are critical mediators of immunity against chronic viral infection and cancer. However, when CD8<sup>+</sup> T cells are persistently exposed to high amounts of antigen, they lose their ... -
Postoperative Infusionstherapie kristalloid versus kolloidal auf der kinderkardiochirurgischen Intensivstation
Wienhold, Carolin (2025-12-17)Die perioperative Flüssigkeitstherapie mit kristalloiden und kolloidalen Lösungen besitzt insb. bei der Behandlung pädiatrischer Patienten eine hohe klinische Relevanz, wobei die verfügbare Evidenzlage bislang unzureichend ... -
Einfluss akuter körperlicher Belastungen unterschiedlicher Intensität auf Exekutivfunktionen kognitiver Ruhenetzwerke: Eine resting-state fMRI-Studie
Bodensohn, Luisa Christine Birgit (2025-12-17)Die Auswirkungen von akuter körperlicher Aktivität auf die kognitive Leistung und die funktionelle Konnektivität in Ruhenetzwerken (RSN) wurden erst in wenigen Studien gemeinsam untersucht und sind bisher nicht vollständig ... -
Glucose-weighted CEST MRI in Adipose Tissue and Sepsis induced AKI
Vo, Van Nhat Minh (2025-12-12)CEST is an advanced MRI technique that is widely used today in both clinical and research. In particular, glucoCEST can be alternative to the contrast enhancement MRI technique using gadolinium (M. Kim et al., 2022). In ... -
Zusammenhang von Eosinophilie und Atherosklerose bei Patienten mit Asthma bronchiale
Frisch, Ben Christoph (2025-12-12)<strong>Hintergrund und Zielsetzung</strong><br /> Asthma ist eine entzündliche Erkrankung, die mit Atherosklerose in Verbindung steht. Die gemeinsamen Mediatoren dieser Entzündung sind jedoch bislang nicht identifiziert ... -
Imaging Biomarkers in Spinocerebellar Ataxias
da Cruz Mota Ferreira, Mónica Rafaela (2025-12-11)Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder with multisystem involvement and no disease-modifying treatment to date. As targeted therapies move into clinical testing, the need for ... -
Determinants and correlates of lipid profiles and their relation with human health
Landstra, Elvire Nadieh (2025-12-10)Lipids are one of the most abundant and diverse molecules in the human body; our lipid profile consists of thousands of unique lipids. Everyone's profile is unique, and is the result of internal processes, genetics, and ...






















