Medizinische Fakultät: Medizinische Fakultät: Neuzugänge
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Fibroblast growth factor receptor 2 (FGFR2) genetic polymorphisms contribute to fused roots in human molars
(2025-04-10)Fibroblast growth factors (FGFRs) signaling are required for human tooth development. Its dysregulation affects tooth formation and patients with <em>FGFR2</em> mutations often present dental anomalies in the spectrum of ... -
Alterations in dopaminergic innervation and receptors in focal cortical dysplasia
(2025-04-16)Focal cortical dysplasia (FCD) type 2 is the most common malformation of cortical development associated with pharmaco-resistant focal epilepsy and frequently located in the frontal cortex. Neuropathological hallmarks ... -
The PJI-TNM Classification as Predictor for Revision-Free Implant Survival Rates in Patients with Periprosthetic Joint Infection of the Hip or Knee Joint
(2025-05-15)Background: Periprosthetic joint infections (PJIs) remain a major challenge in arthroplasty. This study tries to evaluate the PJI-TNM classification as predictor for the revision-free implant survival in patients with PJI ... -
Quality Management Outweighs Pandemic: Retrospective Analysis Shows Improved Quality of Care for Staphylococcus aureus Bacteremia Despite SARS-CoV-2
(2025-03-30)Background: <em>Staphylococcus aureus</em> bacteremia (SAB) is of great clinical relevance, as it is the most common type of bacteremia. Several studies show that the quality of care and thus the outcome can be positively ... -
Intraoperative Profiling of the Supracrestal Implant Complex Minimizes Peri-Implant Crestal Bone Remodeling: The Guided Bone Profiling Concept
(2025-03-08)(1) Background: Early-stage bone resorption following implant placement can significantly impact the long-term success of implants. This study evaluates whether a fully digitally planned implant position based on the E-point ... -
Robust COVID-19 Vaccine Responses Despite Filarial Co-Infection: Insights from a Lymphatic Filariasis Cohort in Ghana
(2025-03-13)Background/Objectives: Although the COVID-19 pandemic has largely concluded, the varied trajectories it has followed in different regions of the world remain incompletely understood. Intensive research is needed to fully ... -
Optogenetic quantification of cardiac excitability and electrical coupling in intact hearts to explain cardiac arrhythmia initiation
(2025-02-28)Increased cardiac excitability and reduced electrical coupling promote cardiac arrhythmia and can be quantified by input resistance (<em>R<sub>m</sub></em>), pacing threshold (<em>I<sub>thr</sub></em>), and cardiac space ... -
Psychological safety, job satisfaction, and the intention to leave among German early-career physicians
(2025-01-17)<strong>Background</strong> Healthcare systems worldwide experience shortages of healthcare professionals. Retention of physicians is becoming an increasing problem. The psychological safety among physicians affects not ... -
Trajectories of Mental Distress and Resilience During the COVID-19 Pandemic Among Healthcare Workers
(2025-03-06)<strong>Background/Objectives:</strong> The recent COVID-19 pandemic posed a significant psychological challenge for healthcare workers. Resilience and the extent of psychological stress varied across professional groups ... -
Retrospektive Analyse nativer Kniegelenksinfektionen: Einfluss klinischer, mikrobiologischer und laborchemischer Faktoren auf den klinischen Verlauf und Therapieerfolg
(2025-10-24)Die Inzidenz des nativen Kniegelenkinfekts steigt in den letzten Jahren stetig ein. Eine schnelle Diagnosesicherung ist notwendig, um schwerwiegende Gelenkdestruktionen, Funktionseinschränkungen oder auch eine Sepsis zu ... -
Risikofaktoren der Brushitsteinbildung
(2025-10-24)Ziel der Untersuchung war es Risikofaktoren der Brushitsteinbildung zu identifizieren und den Einfluss der Ernährung zu ermitteln. Dafür wurden metabolische und ernährungsbedingte Daten sowie die 24-Stunden-Urine von 65 ... -
Nahrungsmittelunverträglichkeiten bei Hashimoto-Thyreoiditis
(2025-10-23)Die Hashimoto-Thyreoiditis (HT) ist eine chronisch-entzündliche Autoimmunerkrankung der Schilddrüse, die vor allem Frauen betrifft. Auch bei euthyreoter Stoffwechsellage berichten viele Patientinnen und Patienten über ... -
Investigating the impact of polymorphisms in the ANKK1 and DRD2 genes on oral health-related quality of life in male patients with temporomandibular disorders
(2025-06-20)<strong>Introduction:</strong> Previous studies have reported that genetic polymorphisms may impact the signs and symptoms of temporomandibular disorder (TMD). Therefore, this study aimed to investigate the association ... -
Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness
(2025-02-20)<strong>Background: </strong>Asthma is associated with atherosclerosis and abdominal aortic aneurysm (AAA). However, the underlying pathomechanisms remain elusive. Blood eosinophil count (BEC) is implicated in both ... -
Beneficial effects of non-invasive physical plasma on human periodontal ligament cells in vitro
(2024-11-19)<strong>Introduction:</strong> Periodontitis is a chronic inflammatory disease of the periodontium that can lead to the loss of affected teeth if left untreated. It is induced by a multifactorial process centered on microbial ... -
First-Line Treatment for Advanced Hepatocellular Carcinoma: A Three-Armed Real-World Comparison
(2024-01-13)<strong>Background and Aim:</strong> There are several existing systemic 1st- line therapies for advanced hepatocellular carcinoma (HCC), including atezolizumab/bevacizumab (Atez/Bev), sorafenib and lenvatinib. This study ... -
Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators
(2024-07-23)Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using optical imaging. The viral transduction of GECIs is commonly used to target expression ... -
Use of the FallAkte Plus System as an IT Infrastructure for the North Rhine-Westphalian General Practice Research Network: Mixed Methods Usability Study
(2024-05-20)<strong>Background:</strong> Primary care research networks can generate important information in the setting where most patients are seen and treated. However, this requires a suitable IT infrastructure (ITI), which the ... -
Assessing Electronic Health Literacy in Individuals With the Post–COVID-19 Condition Using the German Revised eHealth Literacy Scale: Validation Study
(2024-04-25)<strong>Background:</strong> The eHealth Literacy Scale (eHEALS) is a widely used instrument for measuring eHealth literacy (eHL). However, little is known so far about whether the instrument is valid for the assessment ... -
Prospective effects of an artificial intelligence-based computer-aided detection system for prostate imaging on routine workflow and radiologists' outcomes
(2023-12-06)<em>Objectives:</em> Artificial intelligence (AI) is expected to alleviate the negative consequences of rising case numbers for radiologists. Currently, systematic evaluations of the impact of AI solutions in real-world ...
